Deep mutational scanning: a new style of protein science
Mutagenesis provides insight into proteins, but only recently have assays that couple
genotype to phenotype been used to assess the activities of as many as 1 million mutant …
genotype to phenotype been used to assess the activities of as many as 1 million mutant …
Structural and physico-chemical effects of disease and non-disease nsSNPs on proteins
Highlights•Missense mutations frequently alter protein biophysical characteristics such as
stability, dynamics and interactions.•Protein biophysical properties are interrelated and …
stability, dynamics and interactions.•Protein biophysical properties are interrelated and …
SKEMPI 2.0: an updated benchmark of changes in protein–protein binding energy, kinetics and thermodynamics upon mutation
J Jankauskaitė, B Jiménez-García, J Dapkūnas… - …, 2019 - academic.oup.com
Motivation Understanding the relationship between the sequence, structure, binding energy,
binding kinetics and binding thermodynamics of protein–protein interactions is crucial to …
binding kinetics and binding thermodynamics of protein–protein interactions is crucial to …
Prediction of protein assemblies, the next frontier: The CASP14‐CAPRI experiment
MF Lensink, G Brysbaert, T Mauri… - Proteins: Structure …, 2021 - Wiley Online Library
We present the results for CAPRI Round 50, the fourth joint CASP‐CAPRI protein assembly
prediction challenge. The Round comprised a total of twelve targets, including six dimers …
prediction challenge. The Round comprised a total of twelve targets, including six dimers …
Impact of AlphaFold on structure prediction of protein complexes: The CASP15‐CAPRI experiment
MF Lensink, G Brysbaert, N Raouraoua… - Proteins: Structure …, 2023 - Wiley Online Library
We present the results for CAPRI Round 54, the 5th joint CASP‐CAPRI protein assembly
prediction challenge. The Round offered 37 targets, including 14 homodimers, 3 homo …
prediction challenge. The Round offered 37 targets, including 14 homodimers, 3 homo …
Modeling protein–protein and protein–peptide complexes: CAPRI 6th edition
MF Lensink, S Velankar… - … : Structure, Function, and …, 2017 - Wiley Online Library
We present the sixth report evaluating the performance of methods for predicting the atomic
resolution structures of protein complexes offered as targets to the community‐wide initiative …
resolution structures of protein complexes offered as targets to the community‐wide initiative …
Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies
Development of strategies for induction of HIV-1 broadly neutralizing antibodies (bnAbs) by
vaccines is a priority. Determining the steps of bnAb induction in HIV-1-infected individuals …
vaccines is a priority. Determining the steps of bnAb induction in HIV-1-infected individuals …
Modeling protein‐protein, protein‐peptide, and protein‐oligosaccharide complexes: CAPRI 7th edition
MF Lensink, N Nadzirin, S Velankar… - Proteins: Structure …, 2020 - Wiley Online Library
We present the seventh report on the performance of methods for predicting the atomic
resolution structures of protein complexes offered as targets to the community‐wide initiative …
resolution structures of protein complexes offered as targets to the community‐wide initiative …
Docking, scoring, and affinity prediction in CAPRI
MF Lensink, SJ Wodak - Proteins: Structure, Function, and …, 2013 - Wiley Online Library
We present the fifth evaluation of docking and related scoring methods used in the
community‐wide experiment on the Critical Assessment of Predicted Interactions (CAPRI) …
community‐wide experiment on the Critical Assessment of Predicted Interactions (CAPRI) …
[HTML][HTML] Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health
HC Jubb, AP Pandurangan, MA Turner… - Progress in biophysics …, 2017 - Elsevier
Many essential biological processes including cell regulation and signalling are mediated
through the assembly of protein complexes. Changes to protein-protein interaction (PPI) …
through the assembly of protein complexes. Changes to protein-protein interaction (PPI) …