Mutagenesis provides insight into proteins, but only recently have assays that couple
genotype to phenotype been used to assess the activities of as many as 1 million mutant …

Highlights•Missense mutations frequently alter protein biophysical characteristics such as
stability, dynamics and interactions.•Protein biophysical properties are interrelated and …

Motivation Understanding the relationship between the sequence, structure, binding energy,
binding kinetics and binding thermodynamics of protein–protein interactions is crucial to …

We present the results for CAPRI Round 50, the fourth joint CASP‐CAPRI protein assembly
prediction challenge. The Round comprised a total of twelve targets, including six dimers …

We present the sixth report evaluating the performance of methods for predicting the atomic
resolution structures of protein complexes offered as targets to the community‐wide initiative …

Development of strategies for induction of HIV-1 broadly neutralizing antibodies (bnAbs) by
vaccines is a priority. Determining the steps of bnAb induction in HIV-1-infected individuals …

We present the seventh report on the performance of methods for predicting the atomic
resolution structures of protein complexes offered as targets to the community‐wide initiative …

We present the fifth evaluation of docking and related scoring methods used in the
community‐wide experiment on the Critical Assessment of Predicted Interactions (CAPRI) …

Many essential biological processes including cell regulation and signalling are mediated
through the assembly of protein complexes. Changes to protein-protein interaction (PPI) …

Antibodies (Abs) are a crucial component of the immune system and are often used as
diagnostic and therapeutic agents. The need for high‐affinity and high‐specificity antibodies …