Exosomes are small membrane vesicles (ranging from 30 nm to 150 nm), secreted by
different cell types upon fusion of multivesicular bodies (MVB) to the cell plasma membrane …

Effective regulation of immune-cell activation is critical for ensuring that the immune
response, and inflammation generated for the purpose of pathogen elimination, are limited …

Minichromosome maintenance complex component 7 (MCM7) belongs to the
minichromosome maintenance family that is important for the initiation of eukaryotic DNA …

Despite the recent advances in cancer research and treatment, gastrointestinal (GI) cancers
remain the most common deadly disease worldwide. The aberrant DNA replication serves …

Background The effective treatment of triple-negative breast cancer (TNBC) remains a
profound clinical challenge. Despite frequent epidermal growth factor receptor (EGFR) …

Background Epidermal growth factor receptor (EGFR), a well-known oncogenic driver,
contributes to the initiation and progression of a wide range of cancer types. Aberrant lipid …

Members of the Src family of kinases (SFKs) are non-receptor tyrosine kinases involved in
numerous signal transduction pathways. The catalytic, SH3 and SH2 domains are attached …

Survival of chronic lymphocytic leukemia (CLL) cells strictly depends on the support of an
appropriate tumor microenvironment. Here, we demonstrate that LYN kinase is essential for …

Hepatocellular carcinoma (HCC) has a high mortality rate due to the lack of effective
treatments and drugs. Arsenic trioxide (ATO), which has been proved to successfully treat …

Systemic lupus erythematosus (SLE, lupus) is a debilitating, multisystem autoimmune
disease that can affect any organ in the body. The disease is characterized by circulating …