Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is a central method in
epigenomic research. Genome-wide analysis of histone modifications, such as enhancer …

Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …

INTRODUCTION Nearly all cells in the human body share the same primary genome
sequence consisting of four nucleotide bases. One of the bases, cytosine, is commonly …

Background: N 6-Methyladenosine (m6A) methylation is the most prevalent internal
posttranscriptional modification on mammalian mRNA. The role of m6A mRNA methylation …

Genomic enhancers are important regulators of gene expression, but their identification is a
challenge, and methods depend on indirect measures of activity. We developed a method …

Epigenomic profiling by chromatin immunoprecipitation coupled with massively parallel
DNA sequencing (ChIP-seq) is a prevailing methodology used to investigate chromatin …

YAP1 is a major effector of the Hippo pathway and a well-established oncogene. Elevated
YAP1 activity due to mutations in Hippo pathway components or YAP1 amplification is …

Human higher cognition is attributed to the evolutionary expansion and elaboration of the
human cerebral cortex. However, the genetic mechanisms contributing to these …

Mapping the chromosomal locations of transcription factors, nucleosomes, histone
modifications, chromatin remodeling enzymes, chaperones, and polymerases is one of the …

Background Development of eukaryotic organisms is controlled by transcription factors that
trigger specific and global changes in gene expression programs. In plants, MADS-domain …