Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches

B Zeng, A Wei, Q Zhou, M Yuan, K Lei… - Phytotherapy …, 2022 - Wiley Online Library
Abstract Andrographis paniculata (Burm. f.) Wall. ex Nees, a renowned herb medicine in
China, is broadly utilized in traditional Chinese medicine (TCM) for the treatment of cold and …

Self-assembly of amphiphilic compounds as a versatile tool for construction of nanoscale drug carriers

R Kashapov, G Gaynanova, D Gabdrakhmanov… - International Journal of …, 2020 - mdpi.com
This review focuses on synthetic and natural amphiphilic systems prepared from straight-
chain and macrocyclic compounds capable of self-assembly with the formation of nanoscale …

Formulation of nanomicelles to improve the solubility and the oral absorption of silymarin

V Piazzini, M D'Ambrosio, C Luceri, L Cinci, E Landucci… - Molecules, 2019 - mdpi.com
Two novel nanomicellar formulations were developed to improve the poor aqueous
solubility and the oral absorption of silymarin. Polymeric nanomicelles made of Soluplus and …

Chitosan coated human serum albumin nanoparticles: A promising strategy for nose-to-brain drug delivery

V Piazzini, E Landucci, M D'Ambrosio… - International journal of …, 2019 - Elsevier
The aim of the present study was the development of human serum albumin nanoparticles
(HSA NPs) as nose-to-brain carrier. To strengthen, the efficacy of nanoparticles as drug …

Paclitaxel/methotrexate co-loaded PLGA nanoparticles in glioblastoma treatment: Formulation development and in vitro antitumor activity evaluation

F Madani, SS Esnaashari, MC Bergonzi, TJ Webster… - Life sciences, 2020 - Elsevier
Aim The aim of this study was to improve the therapeutic index of chemotherapeutic drugs
on glioblastoma cells through an improved co-drug delivery system. Materials and methods …

Anticancer potential of andrographolide from Andrographis paniculata (Burm. f.) Nees and its mechanisms of action

Z Malik, R Parveen, B Parveen, S Zahiruddin… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Synthetic drugs used for cancer treatment have side
effects that may be immunosupressive, can cause liver, kidney and cardiac toxicity, and …

Modulation of engineered nanomaterial interactions with organ barriers for enhanced drug transport

V Lenders, X Koutsoumpou, P Phan… - Chemical Society …, 2023 - pubs.rsc.org
The biomedical use of nanoparticles (NPs) has been the focus of intense research for over a
decade. As most NPs are explored as carriers to alter the biodistribution, pharmacokinetics …

[HTML][HTML] Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases

T Gou, M Hu, M Xu, Y Chen, R Chen, T Zhou… - Journal of …, 2023 - Elsevier
Atherosclerotic cardiovascular disease (ASCVD) frequently results in sudden death and
poses a serious threat to public health worldwide. The drugs approved for the prevention …

Recent advancements in liposome-targeting strategies for the treatment of gliomas: a systematic review

J Li, T Tan, L Zhao, M Liu, Y You, Y Zeng… - ACS Applied Bio …, 2020 - ACS Publications
Malignant tumors represent some of the most intractable diseases that endanger human
health. A glioma is a tumor of the central nervous system that is characterized by severe …

Enhanced dissolution, permeation and oral bioavailability of aripiprazole mixed micelles: In vitro and in vivo evaluation

V Piazzini, E Landucci, M Urru, A Chiarugi… - International Journal of …, 2020 - Elsevier
Aripiprazole (ARP) is an antipsychotic drug approved for the treatment of schizophrenia. It is
poorly water-soluble and undergoes extensive hepatic metabolism and P-gp efflux, which …