M itochondrial DNA and primary mitochondrial dysfunction in P arkinson's disease
In 1979, it was observed that parkinsonism could be induced by a toxin inhibiting
mitochondrial respiratory complex I. This initiated the long‐standing hypothesis that …
mitochondrial respiratory complex I. This initiated the long‐standing hypothesis that …
The first horse herders and the impact of early Bronze Age steppe expansions into Asia
P de Barros Damgaard, R Martiniano, J Kamm… - Science, 2018 - science.org
INTRODUCTION According to the commonly accepted “steppe hypothesis,” the initial
spread of Indo-European (IE) languages into both Europe and Asia took place with …
spread of Indo-European (IE) languages into both Europe and Asia took place with …
The genetic history of ice age Europe
Modern humans arrived in Europe~ 45,000 years ago, but little is known about their genetic
composition before the start of farming~ 8,500 years ago. Here we analyse genome-wide …
composition before the start of farming~ 8,500 years ago. Here we analyse genome-wide …
The case for the continuing use of the revised Cambridge Reference Sequence (rCRS) and the standardization of notation in human mitochondrial DNA studies
HJ Bandelt, A Kloss-Brandstätter, MB Richards… - Journal of human …, 2014 - nature.com
Since the determination in 1981 of the sequence of the human mitochondrial DNA (mtDNA)
genome, the Cambridge Reference Sequence (CRS), has been used as the reference …
genome, the Cambridge Reference Sequence (CRS), has been used as the reference …
Impaired complex I repair causes recessive Leber's hereditary optic neuropathy
SL Stenton, NL Sheremet, CB Catarino… - The Journal of …, 2021 - Am Soc Clin Investig
Leber's hereditary optic neuropathy (LHON) is the most frequent mitochondrial disease and
was the first to be genetically defined by a point mutation in mitochondrial DNA (mtDNA). A …
was the first to be genetically defined by a point mutation in mitochondrial DNA (mtDNA). A …
Early Neolithic genomes from the eastern Fertile Crescent
We sequenced Early Neolithic genomes from the Zagros region of Iran (eastern Fertile
Crescent), where some of the earliest evidence for farming is found, and identify a previously …
Crescent), where some of the earliest evidence for farming is found, and identify a previously …
Yersinia pestis and the Plague of Justinian 541–543 AD: a genomic analysis
Background Yersinia pestis has caused at least three human plague pandemics. The
second (Black Death, 14–17th centuries) and third (19–20th centuries) have been …
second (Black Death, 14–17th centuries) and third (19–20th centuries) have been …
Neolithic and Bronze Age migration to Ireland and establishment of the insular Atlantic genome
The Neolithic and Bronze Age transitions were profound cultural shifts catalyzed in parts of
Europe by migrations, first of early farmers from the Near East and then Bronze Age herders …
Europe by migrations, first of early farmers from the Near East and then Bronze Age herders …
Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins
Abstract The Ashkenazi Jewish (AJ) population is a genetic isolate close to European and
Middle Eastern groups, with genetic diversity patterns conducive to disease mapping. Here …
Middle Eastern groups, with genetic diversity patterns conducive to disease mapping. Here …
Reconciling migration models to the Americas with the variation of North American native mitogenomes
A Achilli, UA Perego, H Lancioni… - Proceedings of the …, 2013 - National Acad Sciences
In this study we evaluated migration models to the Americas by using the information
contained in native mitochondrial genomes (mitogenomes) from North America. Molecular …
contained in native mitochondrial genomes (mitogenomes) from North America. Molecular …