Inferring microenvironmental regulation of gene expression from single-cell RNA sequencing data using scMLnet with an application to COVID-19
J Cheng, J Zhang, Z Wu, X Sun - Briefings in bioinformatics, 2021 - academic.oup.com
Inferring how gene expression in a cell is influenced by cellular microenvironment is of great
importance yet challenging. In this study, we present a single-cell RNA-sequencing data …
importance yet challenging. In this study, we present a single-cell RNA-sequencing data …
The Role of BRCA1/2-Mutated Tumor Microenvironment in Breast Cancer
S Miklikova, L Trnkova, J Plava, M Bohac, M Kuniakova… - Cancers, 2021 - mdpi.com
Simple Summary The link between BRCA1/2 mutations and high susceptibility to breast
cancer development has been well-established for years. However, the potential impact of …
cancer development has been well-established for years. However, the potential impact of …
Patient-specific multi-omics models and the application in personalized combination therapy
A John, B Qin, KR Kalari, L Wang, J Yu - Future Oncology, 2020 - Taylor & Francis
The rapid advancement of high-throughput technologies and sharp decrease in cost have
opened up the possibility to generate large amount of multi-omics data on an individual …
opened up the possibility to generate large amount of multi-omics data on an individual …
MeSHHeading2vec: a new method for representing MeSH headings as vectors based on graph embedding algorithm
Abstract Effectively representing Medical Subject Headings (MeSH) headings (terms) such
as disease and drug as discriminative vectors could greatly improve the performance of …
as disease and drug as discriminative vectors could greatly improve the performance of …
A computational study of potential miRNA-disease association inference based on ensemble learning and kernel ridge regression
As increasing experimental studies have shown that microRNAs (miRNAs) are closely
related to multiple biological processes and the prevention, diagnosis and treatment of …
related to multiple biological processes and the prevention, diagnosis and treatment of …
Comparative analysis of protein-protein interaction networks in metastatic breast cancer
H Hozhabri, RS Ghasemi Dehkohneh, SM Razavi… - PloS one, 2022 - journals.plos.org
Metastatic lesions leading causes of the majority of deaths in patients with the breast cancer.
The present study aimed to provide a comprehensive analysis of the differentially expressed …
The present study aimed to provide a comprehensive analysis of the differentially expressed …
Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response
With the continued promise of immunotherapy for treating cancer, understanding how host
genetics contributes to the tumor immune microenvironment (TIME) is essential to tailoring …
genetics contributes to the tumor immune microenvironment (TIME) is essential to tailoring …
Identification and analysis of genes associated with epithelial ovarian cancer by integrated bioinformatics methods
T Gui, C Yao, B Jia, K Shen - PLoS One, 2021 - journals.plos.org
Background Though considerable efforts have been made to improve the treatment of
epithelial ovarian cancer (EOC), the prognosis of patients has remained poor. Identifying …
epithelial ovarian cancer (EOC), the prognosis of patients has remained poor. Identifying …
Plasma exosome-derived microRNAs expression profiling and bioinformatics analysis under cross-talk between increased low-density lipoprotein cholesterol level …
C Liu, Y Lai, S Ying, J Zhan, Y Shen - Journal of Translational Medicine, 2020 - Springer
Background Exosome-derived microRNAs (exo-miRs) as messengers play important roles,
in the cross-talk between genetic [ATP-sensitive potassium channels (KATP) genetic variant …
in the cross-talk between genetic [ATP-sensitive potassium channels (KATP) genetic variant …
Breast Tumor Metastasis and Its Microenvironment: It Takes Both Seed and Soil to Grow a Tumor and Target It for Treatment
S Bonni, DN Brindley, MD Chamberlain… - Cancers, 2024 - mdpi.com
Simple Summary Metastasis is one of the biggest challenges in treating breast cancer.
Breast tumors grow in different areas such as the brain, lungs and bone and have distinct …
Breast tumors grow in different areas such as the brain, lungs and bone and have distinct …