Biomolecular condensates compartmentalize and regulate assemblies of biomolecules
engaged in vital physiological processes in cells. Specific proteins and nucleic acids …

Ribonucleoprotein (RNP) granules are diverse membrane-less organelles that form through
multivalent RNA-RNA, RNA-protein, and protein-protein interactions between RNPs. RNP …

Diverse mechanisms have been described for selective enrichment of biomolecules in
membrane-bound organelles, but less is known about mechanisms by which molecules are …

RNA granules are mesoscale assemblies that form in the absence of limiting membranes.
RNA granules contain factors for RNA biogenesis and turnover and are often assumed to …

Insulin receptor (IR) signaling is central to normal metabolic control and is dysregulated in
metabolic diseases such as type 2 diabetes. We report here that IR is incorporated into …

Biomolecular condensates, formed through phase separation, are upending our
understanding in much of molecular, cell, and developmental biology. There is an urgent …

Liquid-liquid phase separation (LLPS) of proteins is thought to be a primary driving force for
the formation of membraneless organelles, which control a wide range of biological …

The regulation and preservation of distinct intracellular and extracellular solute
microenvironments is crucial for the maintenance of cellular homeostasis. In mammals, the …

Chromatin regulatory processes physically take place in the environment of the cell nucleus,
which is filled with the chromosomes and a plethora of smaller biomolecules. The nucleus …

Biomolecular condensates play important roles in a wide array of fundamental biological
processes, such as cellular compartmentalization, cellular regulation, and other biochemical …