Psychedelics are serotonin 2A receptor agonists that can lead to profound changes in
perception, cognition and mood. In this review, we focus on the basic neurobiology …

This theoretical article revives a classical bridging construct, canalization, to describe a new
model of a general factor of psychopathology. To achieve this, we have distinguished …

Psychedelics have attracted medical interest, but their effects on human brain function are
incompletely understood. In a comprehensive, within-subjects, placebo-controlled design …

This paper introduces a new construct, the 'pivotal mental state', which is defined as a hyper-
plastic state aiding rapid and deep learning that can mediate psychological transformation …

How profoundly can humans change their own minds? In this paper we offer a unifying
account of deconstructive meditation under the predictive processing view. We start from …

To understand how pharmacological interventions can exert their powerful effects on brain
function, we need to understand how they engage the brain's rich neurotransmitter …

Understanding the phenomenology and content of the inhaled N, N, dimethyltryptamine (N,
N-DMT) experience is critical to facilitate and support ongoing research and therapeutic …

Addressing global mental health is a major 21st-century challenge. Current treatments have
recognized limitations; in this context, new ones that are prophylactic and effective across …

Psychedelics are undergoing a major resurgence of scientific and clinical interest. While
multiple theories and frameworks have been proposed, there is yet no universal agreement …

Previous research has associated alpha-band [8–12 Hz] oscillations with inhibitory
functions: for instance, several studies showed that visual attention increases alpha-band …