With a growing aged population, there is an imminent need to develop new therapeutic
strategies to ameliorate disorders of hematopoietic aging, including clonal hematopoiesis …

Hematopoietic system (HS) is one of the most unique, adaptive and comprehensive
developmental systems on which various other body systems relies on. It consists of a …

Clonal hematopoiesis (CH) is an aging-associated condition characterized by the clonal
outgrowth of pre-leukemic cells that acquire specific mutations. Although individuals with CH …

Hematopoietic stem cells (HSCs) produce all blood cell lineages and maintain life‐long
hematopoiesis. However, the self‐renewal ability and differentiation capacity of HSCs …

Macrophages play a crucial role in the development and control of inflammation.
Understanding the mechanisms balancing macrophage inflammatory activity is important to …

Abstract Interleukin 22 (IL-22) has a non-redundant role in immune defence of the intestinal
barrier,–. T cells, but not innate lymphoid cells, have an indispensable role in sustaining the …

RUNX1 is a Runt family transcription factor that plays a critical role in normal hematopoiesis,
including the differentiation and proliferation of hematopoietic cells. RUNX1 mutations …

Clonal hematopoiesis (CH) is the age-related expansion of hematopoietic stem cell clones
caused by the acquisition of somatic point mutations or mosaic chromosomal alterations …

Background The aging inflammatory microenvironment surrounding Leydig cells is linked to
reduced testosterone levels in males. Tumor necrosis factor alpha-induced protein 3 …

Background: To explore advanced glycation end products (AGEs)-induced m6A modification
in fibroblasts and its potential role in photoaging. Methods: We studied m6A modification in …