Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a
broad range of cellular and metabolic functions carried out in a variety of cellular …

Measures of the functional and structural properties of blood vessels can be used to assess
preclinical stage of vascular disorders. Recent experimental and population studies show …

Short chain fatty acid (SCFA) metabolites are byproducts of gut microbial metabolism that
are known to affect host physiology via host G protein-coupled receptor (GPCRs). We …

Objective To examine the association of long term intake of gluten with the development of
incident coronary heart disease. Design Prospective cohort study. Setting and participants …

The socioeconomic and medical improvements of the last decades have led to a relevant
increase in the median age of worldwide population. Although numerous studies described …

Evidence links osteoporosis and cardiovascular disease but the cellular and molecular
mechanisms are unclear. Here we identify skeleton-secreted platelet-derived growth factor …

Ageing leads to a progressive deterioration of structure and function of all organs over the
time. During this process endothelial cells undergo senescence and manifest significant …

Despite significant research efforts, clinical practice for arterial bypass surgery has been
stagnant, and engineered grafts continue to face postimplantation challenges. Here, we …

Aging leads to central artery stiffening and associated hemodynamic sequelae. Because
healthy arteries exhibit differential geometry, composition, and mechanical behaviors along …

Background Endothelial dysfunction and arterial stiffening play major roles in cardiovascular
diseases. The critical role for the miR-181 family in vascular inflammation has been …