Digestive cancers are the leading cause of cancer-related death worldwide and have high
risks of morbidity and mortality. Histone methylation, which is mediated mainly by lysine …

Pancreatic ductal adenocarcinoma (PDAC) remains a major health problem because it
induces almost systematic mortality. Carcinogenesis begins with genetic aberrations which …

Background Bladder cancer (BC) is the most common cancer of the urinary bladder and
upper tract, in which the clinical management is limited. AURKA (aurora kinase A) has been …

While several marine natural products bearing the 2, 5-diketopiperazine ring have been
reported to date, the unique chemistry of dimeric frameworks appears to remain neglected …

Pancreatic cancer has one of the highest mortality rates among all types of cancers. The
disease is highly aggressive and typically diagnosed in late stage making it difficult to treat …

The pharmacoepigenetic apparatus is integrated by gene clusters of different categories,
including (i) pathogenic genes involved in disease pathogenesis,(ii) mechanistic genes …

Background Systems biology leveraging multi-OMICs technologies, is rapidly advancing
development of precision therapies and matching patients to targeted therapies, leading to …

Mitosis entails mechanistic changes required for maintaining the genomic integrity in all
dividing cells. The process is intricate and temporally and spatially regulated by the ordered …

Because of its dismal outcome, pancreatic ductal adenocarcinoma (PDAC) remains a
therapeutic challenge making the testing of new pharmacologic tools a goal of paramount …

We have previously demonstrated that pre-and early postnatal malnutrition in sheep
induced depot-and sex-specific changes in adipose morphological features, metabolic …