Systematic literature review and validity evaluation of the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite (MSFC) in …

S Meyer-Moock, YS Feng, M Maeurer, FW Dippel… - BMC neurology, 2014 - Springer
Background There are a number of instruments that describe severity and progression of
multiple sclerosis and they are increasingly used as endpoints to assess the effectiveness of …

Outcome measures in clinical trials for multiple sclerosis

CEP van Munster, BMJ Uitdehaag - CNS drugs, 2017 - Springer
Due to the heterogeneous nature of the disease, it is a challenge to capture disease activity
of multiple sclerosis (MS) in a reliable and valid way. Therefore, it can be difficult to assess …

The metric properties of a novel non‐motor symptoms scale for Parkinson's disease: results from an international pilot study

KR Chaudhuri, P Martinez‐Martin… - Movement …, 2007 - Wiley Online Library
Non‐motor symptoms (NMS) in Parkinson's disease (PD) are common, significantly reduce
quality of life and at present there is no validated clinical tool to assess the progress or …

Health-related quality of life in multiple sclerosis: direct and indirect effects of comorbidity

LI Berrigan, JD Fisk, SB Patten, H Tremlett, C Wolfson… - Neurology, 2016 - AAN Enterprises
Objective: To evaluate the direct and indirect influences of physical comorbidity, symptoms
of depression and anxiety, fatigue, and disability on health-related quality of life (HRQoL) in …

Prevalence of nonmotor symptoms in Parkinson's disease in an international setting; study using nonmotor symptoms questionnaire in 545 patients

P Martinez‐Martin, AHV Schapira… - … : official journal of the …, 2007 - Wiley Online Library
Abstract 2006, there was, no single instrument (questionnaire or scale) for attempting a
comprehensive assessment of the wide range of nonmotor symptoms (NMS) of Parkinson's …

Clinical trials in progressive multiple sclerosis: lessons learned and future perspectives

D Ontaneda, RJ Fox, J Chataway - The Lancet Neurology, 2015 - thelancet.com
Progressive multiple sclerosis is characterised clinically by the gradual accrual of disability
independent of relapses and can occur with disease onset (primary progressive) or can be …

Neuropsychiatric symptoms and caregiver's burden in Parkinson's disease

P Martinez-Martin, C Rodriguez-Blazquez… - Parkinsonism & related …, 2015 - Elsevier
Abstract Introduction In Parkinson's disease (PD), neuropsychiatric symptoms (NPS) can be
particularly burdensome for caregivers. The main goal of this study was to assess the impact …

The relationship between body mass index and health-related quality of life: comparing the EQ-5D, EuroQol VAS and SF-6D

TH Sach, GR Barton, M Doherty, KR Muir… - International journal of …, 2007 - nature.com
Background: No other studies have compared the relationship between body mass index
(BMI) and health-related quality of life (HRQL) on more than one utility measure. Estimating …

A survey of self-reported outcome instruments for the foot and ankle

RL Martin, JJ Irrgang - Journal of Orthopaedic & Sports Physical Therapy, 2007 - jospt.org
The information acquired from self-reported outcome instruments is useful only if there is
evidence to support the interpretation of obtained scores. To properly interpret scores, there …

Natural history of vanishing white matter

EMC Hamilton, HDW van der Lei… - Annals of …, 2018 - Wiley Online Library
Objective To comprehensively describe the natural history of vanishing white matter (VWM),
aiming at improving counseling of patients/families and providing natural history data for …