Regulation of immunity during visceral Leishmania infection

V Rodrigues, A Cordeiro-da-Silva, M Laforge… - Parasites & vectors, 2016 - Springer
Unicellular eukaryotes of the genus Leishmania are collectively responsible for a
heterogeneous group of diseases known as leishmaniasis. The visceral form of …

Leishmaniasis drug discovery: recent progress and challenges in assay development

B Zulfiqar, TB Shelper, VM Avery - Drug discovery today, 2017 - Elsevier
Highlights•Leishmaniasis remains a neglected tropical disease, with a high unmet medical
need.•Therapeutic efficacy varies depending on the species of Leishmania parasite.•Leads …

Possibilities and challenges for developing a successful vaccine for leishmaniasis

S Srivastava, P Shankar, J Mishra, S Singh - Parasites & vectors, 2016 - Springer
Leishmaniasis is a vector-borne disease caused by different species of protozoan parasites
of the genus Leishmania. It is a major health problem yet neglected tropical diseases, with …

Leishmaniasis in the Middle East: incidence and epidemiology

N Salam, WM Al-Shaqha, A Azzi - PLoS neglected tropical …, 2014 - journals.plos.org
Leishmaniasis is a major health problem worldwide, with several countries reporting cases
of leishmaniasis resulting in loss of human life or a lifelong stigma because of bodily scars …

Role of cytokines in experimental and human visceral leishmaniasis

M Samant, U Sahu, SC Pandey… - Frontiers in cellular and …, 2021 - frontiersin.org
Visceral Leishmaniasis (VL) is the most fatal form of disease leishmaniasis. To date, there
are no effective prophylactic measures and therapeutics available against VL. Recently, new …

Determinants for the development of visceral leishmaniasis disease

LI McCall, WW Zhang, G Matlashewski - PLoS pathogens, 2013 - journals.plos.org
Leishmaniasis is a vector-borne neglected tropical disease associated with a spectrum of
clinical manifestations, ranging from self-healing cutaneous lesions to fatal visceral …

Immunobiology of visceral leishmaniasis

R Kumar, S Nylén - Frontiers in immunology, 2012 - frontiersin.org
Visceral leishmaniasis (VL), commonly known as kala-azar, is caused by Leishmania
donovani and Leishmania infantum (Leishmania chagasi in the Americas). These …

Molecular diagnosis of visceral leishmaniasis

S Sundar, OP Singh - Molecular diagnosis & therapy, 2018 - Springer
Visceral leishmaniasis (VL), a deadly parasitic disease, is a major public health concern
globally. Countries affected by VL have signed the London Declaration on Neglected …

Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model

R Gomes, C Teixeira, MJ Teixeira… - Proceedings of the …, 2008 - National Acad Sciences
Visceral leishmaniasis (VL) is a fatal disease for humans, and no vaccine is currently
available. Sand fly salivary proteins have been associated with protection against cutaneous …

Leishmaniasis immunopathology—impact on design and use of vaccines, diagnostics and drugs

PM Kaye, I Cruz, A Picado, K Van Bocxlaer… - Seminars in …, 2020 - Springer
Leishmaniasis is a disease complex caused by 20 species of protozoan parasites belonging
to the genus Leishmania. In humans, it has two main clinical forms, visceral leishmaniasis …