Physical activity can treat and prevent depressive symptoms, but its antidepressant
mechanisms are yet to be established. In this review, we comprehensively assess key …

Physical activity is one of the modifiable factors of cognitive decline and dementia with the
strongest evidence. Although many influential reviews have illustrated the neurobiological …

Is the field of cognitive aging irretrievably concerned with decline and deficits, or is it shifting
to emphasize the hope of preservation and enhancement of cognitive function in late life? A …

Exercise has been shown to benefit brain structure and function, particularly in aging
populations. However, the mechanisms by which exercise exerts its effects, especially in …

This review proposes that physical inactivity could be considered a behavior selected by
evolution for resting, and also selected to be reinforcing in life-threatening situations in …

OBJECTIVE: To present a conceptual model explaining the mechanisms for the effect of
physical activity on cognitive and mental health in young people and to conduct a systematic …

Synaptic loss and deficits in functional connectivity are hypothesized to contribute to
symptoms associated with major depressive disorder (MDD) and post-traumatic stress …

Exercise plays a key role in healthy aging by promoting both physical and cognitive function.
Physical function and cognitive function appear to be interrelated and may share common …

A significant body of work has investigated the effects of acute exercise, defined as a single
bout of physical activity, on mood and cognitive functions in humans. Several excellent …

Depression is a common, devastating illness. Current pharmacotherapies help many
patients, but high rates of a partial response or no response, and the delayed onset of the …