Innate immunity serves as the rapid and first-line defense against invading pathogens, and
this process can be regulated at various levels, including epigenetic mechanisms. The …

The IL-36 family of cytokines were identified in the early 2000's as a new subfamily of the IL-
1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory …

Without cystic fibrosis transmembrane conductance regulator–mediated (CFTR-mediated)
HCO3–secretion, airway epithelia of newborns with cystic fibrosis (CF) produce an …

There is an urgent need to identify effective therapies for COVID-19 given that a broadly
available and effective vaccine is likely at least one year away. Here, we identify compounds …

Bromodomain (BD) and extra-terminal domain containing proteins (BET) are chromatin
adapters that bind acetylated histone marks via two tandem BDs, BD1 and BD2, to regulate …

Background RORγt is a transcription factor that enables elaboration of Th17-associated
cytokines (including IL-17 and IL-22) and is proposed as a pharmacological target for severe …

The highly complex and variable genotype–phenotype relationships observed in cystic
fibrosis (CF) have been an area of growing interest since the discovery of the CF …

Cystic fibrosis patients suffer from a progressive, often fatal lung disease, which is based on
a complex interplay between chronic infections, locally accumulating immune cells and …

Epigenetic agents such as bromodomain and extra‐terminal region inhibitors (BETi) slow
tumor growth via tumor intrinsic alterations; however, their effects on antitumor immunity …

Lung transplantation can be lifesaving in end-stage cystic fibrosis (CF), but long-term
survival is limited by chronic lung allograft dysfunction (CLAD). Persistent upper airway …