Transglutaminases (Tgases) are a widely distributed group of enzymes that catalyse the
post-translational modification of proteins by the formation of isopeptide bonds. This occurs …

A specialized tissue type, the keratinizing epithelium, protects terrestrial mammals from
water loss and noxious physical, chemical and mechanical insults. This barrier between the …

Gluten sensitivity typically presents as celiac disease, a common chronic small intestinal
disorder. However, in certain individuals it is associated with dermatitis herpetiformis, a …

'Stratum Corneum Moisturization At The Molecular Level'[1] was published over a decade
ago to review what was known about the biology of a common cosmetic problem called 'dry …

Transglutaminases catalyze the posttranslational modification of proteins referred to as the
R-glutaminyl peptide. airhc y glulur~~ yl transferase reaction (EC 2.3. 2.13). which leads to …

Surface epithelial cells, such as the epidermal keratinocyte, undergo a process of terminal
cell differentiation that results in the construction of a multilayered epithelium. This …

Mechanical stability in many biological materials is provided by the crosslinking of large
structural proteins with gamma-glutamyl-epsilon-lysyl amide bonds. The three-dimensional …

Transglutaminases form a family of proteins that have evolved for specialized functions such
as protein crosslinking in haemostasis, semen coagulation, or keratinocyte cornified …

The stratum corneum of the skin serves as an effective barrier for maintenance of the internal
milieu against the external environment. At the cell periphery of the stratum corneum is the …

We isolated and characterized the gene encoding human transglutaminase (TG) X (TGM5)
and mapped it to the 15q15. 2 region of chromosome 15 by fluorescence in situ …