The epigenetic modifications of histones are versatile marks that are intimately connected to
development and disease pathogenesis including human cancers. In this review, we will …

CTCF has it all. The transcription factor binds to tens of thousands of genomic sites, some
tissue-specific, others ultra-conserved. It can act as a transcriptional activator, repressor and …

A three-dimensional chromatin state underpins the structural and functional basis of the
genome by bringing regulatory elements and genes into close spatial proximity to ensure …

Previous reports of GATA2 mutations have focused on the coding region of the gene or full
gene deletions. We recently identified 2 patients with novel insertion/deletion mutations …

The rapidly increasing quantity of genome-wide chromosome conformation capture data
presents great opportunities and challenges in the computational modeling and …

Epistasis is the phenomenon whereby one polymorphism's effect on a trait depends on other
polymorphisms present in the genome. The extent to which epistasis influences complex …

Background Cell-to-cell heterogeneity is a major driver of cancer evolution, progression, and
emergence of drug resistance. Epigenomic variation at the single-cell level can rapidly …

The binding and contribution of transcription factors (TF) to cell specific gene expression is
often deduced from open-chromatin measurements to avoid costly TF ChIP-seq assays …

Metazoan genomes are highly organized inside the cell nucleus. Topologically associating
domains (TADs) represent the building blocks of genome organization, but their linear …

A growing body of evidence supports the notion that variation in gene regulation plays a
crucial role in both speciation and adaptation. However, a comprehensive functional …