IgA nephropathy

KN Lai, SCW Tang, FP Schena, J Novak… - Nature reviews Disease …, 2016 - nature.com
Abstract Globally, IgA nephropathy (IgAN) is the most common primary glomerulonephritis
that can progress to renal failure. The exact pathogenesis of IgAN is not well defined, but …

[HTML][HTML] New developments in the genetics, pathogenesis, and therapy of IgA nephropathy

R Magistroni, VD D'Agati, GB Appel, K Kiryluk - Kidney international, 2015 - Elsevier
Recent years have brought notable progress in the field of IgA nephropathy. Here, we
highlight important new directions and latest developments, including successful discovery …

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

K Kiryluk, Y Li, F Scolari, S Sanna-Cherchi, M Choi… - Nature …, 2014 - nature.com
We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the
most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals …

Genome-wide association study identifies susceptibility loci for IgA nephropathy

AG Gharavi, K Kiryluk, M Choi, Y Li, P Hou, J Xie… - Nature …, 2011 - nature.com
We carried out a genome-wide association study of IgA nephropathy, a major cause of
kidney failure worldwide. We studied 1,194 cases and 902 controls of Chinese Han …

[HTML][HTML] Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis

K Kiryluk, Y Li, S Sanna-Cherchi… - PLoS …, 2012 - journals.plos.org
IgA nephropathy (IgAN), major cause of kidney failure worldwide, is common in Asians,
moderately prevalent in Europeans, and rare in Africans. It is not known if these differences …

The Tn antigen—structural simplicity and biological complexity

T Ju, VI Otto, RD Cummings - … Chemie International Edition, 2011 - Wiley Online Library
Glycoproteins in animal cells contain a variety of glycan structures that are added co‐and/or
posttranslationally to proteins. Of over 20 different types of sugar–amino acid linkages …

A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy

XQ Yu, M Li, H Zhang, HQ Low, X Wei, JQ Wang… - Nature …, 2012 - nature.com
We performed a two-stage genome-wide association study of IgA nephropathy (IgAN) in
Han Chinese, with 1,434 affected individuals (cases) and 4,270 controls in the discovery …

[HTML][HTML] The genetics and immunobiology of IgA nephropathy

K Kiryluk, J Novak - The Journal of clinical investigation, 2014 - Am Soc Clin Investig
IgA nephropathy (IgAN) represents the leading cause of kidney failure among East Asian
populations and the most frequent form of primary glomerulonephritis among Europeans …

HLA has strongest association with IgA nephropathy in genome-wide analysis

J Feehally, M Farrall, A Boland, DP Gale… - Journal of the …, 2010 - journals.lww.com
Demographic and family studies support the existence of a genetic contribution to the
pathogenesis of IgA nephropathy, but results from genetic association studies of candidate …

Pathogenesis of IgA nephropathy

KN Lai - Nature Reviews Nephrology, 2012 - nature.com
Since its first description in 1968, IgA nephropathy has remained the most common form of
idiopathic glomerulonephritis leading to chronic kidney disease in developed countries. The …