With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

Acetylcholine (ACh), the major neurotransmitter secreted by cholinergic neurons, is widely
found in the peripheral and central nervous systems, and its main function is to complete the …

Positive allosteric modulators (PAMs), negative allosteric modulators (NAMs), silent
agonists, allosteric activating PAMs and neutral or silent allosteric modulators are …

The study of nicotinic acetylcholine receptors (nAChRs) has significantly progressed in the
last decade, due to a) the improved techniques available for structural studies; b) the …

The landscape of worldwide tobacco use is changing, with a decrease in traditional smoking
and an exponential rise in electronic cigarette use. No new nicotine cessation …

Abstract The low sensitivity (α4) 3 (β2) 2 (LS) and high sensitivity (α4) 2 (β2) 3 (HS) nAChR
isoforms may contribute to a variety of brain functions, pathophysiological processes, and …

A series of racemic benzofurans bearing N-methyl-2-pyrrolidinyl residue at C (2) or C (3) has
been synthesized and tested for affinity at the α4β2 and α3β4 nicotine acetylcholine …

Neuropathic pain affects about 7–8% of the population, and its management still poses
challenges with unmet needs. Over the past decades, researchers have explored the …

Abstract 4R is a tobacco cembranoid that binds to and modulates cholinergic receptors and
exhibits neuroprotective and anti-inflammatory activity. Given the established function of the …

Abstract Rationale Ropanicant (SUVN-911)(3-(6-Chloropyridine-3-yloxymethyl)-2-
azabicyclo (3.1. 0) hexane hydrochloride) is a novel α4β2 nicotinic acetylcholine receptor …