One of the most transformative developments in neurogastroenterology is the realization that
many functions normally attributed to enteric neurons involve interactions with enteric glial …

A highly conserved but convoluted network of neurons and glial cells, the enteric nervous
system (ENS), is positioned along the wall of the gut to coordinate digestive processes and …

Chemotherapy—induced gastrointestinal dysfunction is a common occurrence associated
with many different classes of chemotherapeutic agents. Gastrointestinal toxicity includes …

Necrotizing enterocolitis (NEC) is a devastating disease of premature infants, whose
pathogenesis remains incompletely understood, although activation of the Gram-negative …

S100B is a calcium-binding protein mainly concentrated in astrocytes in the nervous system.
Its levels in biological fluids are recognized as a reliable biomarker of active neural distress …

The S100 family proteins possess a variety of intracellular and extracellular functions. They
interact with multiple receptors and signal transducers to regulate pathways that govern …

Berberine (BBR) is an isoquinoline alkaloid, which has been used in the treatment of
intestinal mucositis. However, BBR on chemotherapy-induced mucositis in cancer patients …

Abstract Muscularis Externa Macrophages (ME-Macs) and enteric glial cells (EGCs) are
closely associated cell types in the bowel wall, and important interactions are thought to …

Fluorouracil (5-Fu) is the preferred drug in colorectal cancer treatment. Although 5-Fu
treatment contributes to the increase in survival rates, long-term use of 5-Fu causes severe …

Background Traumatic brain injury (TBI) remains one of the main causes for disability and
death worldwide. While the primary mechanical injury cannot be avoided, the prevention of …