Narcolepsy-cataplexy is a disabling sleep disorder characterized by excessive daytime
sleepiness and abnormal REM sleep. The development of human narcolepsy involves …

The WHO Nomenclature Committee for factors of the HLA system met in Brighton in March
1995 at the joint meeting of the European Foundation for Immunogenetics and British …

To study the mechanism of maintenance of polymorphism at major histocompatibility
complex (MHC) loci, synonymous and nonsynonymous (amino acid-altering) nucleotide …

Abstract Study Objective: Prior research has identified five common genetic variants
associated with narcolepsy with cataplexy in Caucasian patients. To replicate and/or extend …

In the present study, we tested 19 Caucasian and 28 Black American narcoleptics for the
presence of the human leucocyte antigen (HLA) DQB 1* 0602 and DQA1* 0102 (DQ1) …

Narcolepsy is a neurological condition with a prevalence of up to 1 per 1,000 that is
characterized by irresistible bouts of sleep. Associated features include the pathological …

▪ Abstract Human narcolepsy is a genetically complex disorder. Family studies indicate a 20–
40 times increased risk of narcolepsy in first-degree relatives and twin studies suggest that …

Narcolepsy was first shown to be tightly associated with HLA-DR2 and DQ1 in 1983,
suggesting a possible autoimmune mechanism. Early investigations failed to demonstrate …

NARCOLEPSY, a syndrome of excessive sleepiness and abnormalities of rapid-eye-
movement (REM) sleep, 1 is a distinct neurologic disorder with characteristic clinical …

Narcolepsy is considered a homogeneous clinical entity when excessive daytime
sleepiness and cataplexy are present. Cataplexy is a polymorphic symptom that can be very …