Tuberculosis treatment monitoring and outcome measures: new interest and new strategies
J Heyckendorf, SB Georghiou, N Frahm… - Clinical microbiology …, 2022 - Am Soc Microbiol
Despite the advent of new diagnostics, drugs and regimens, tuberculosis (TB) remains a
global public health threat. A significant challenge for TB control efforts has been the …
global public health threat. A significant challenge for TB control efforts has been the …
Reimagining the status quo: How close are we to rapid sputum-free tuberculosis diagnostics for all?
RR Nathavitharana, AL Garcia-Basteiro, M Ruhwald… - …, 2022 - thelancet.com
Rapid, accurate, sputum-free tests for tuberculosis (TB) triage and confirmation are urgently
needed to close the widening diagnostic gap. We summarise key technologies and review …
needed to close the widening diagnostic gap. We summarise key technologies and review …
Immune biomarkers for diagnosis and treatment monitoring of tuberculosis: current developments and future prospects
Tuberculosis (TB) treatment monitoring is paramount to clinical decision-making and the
host biomarkers appears to play a significant role. The currently available diagnostic …
host biomarkers appears to play a significant role. The currently available diagnostic …
Tuberculosis phenotypic and genotypic drug susceptibility testing and immunodiagnostics: a review
KA Yusoof, JI García, A Schami… - Frontiers in …, 2022 - frontiersin.org
Tuberculosis (TB), considered an ancient disease, is still killing one person every 21
seconds. Diagnosis of Mycobacterium tuberculosis (M. tb) still has many challenges …
seconds. Diagnosis of Mycobacterium tuberculosis (M. tb) still has many challenges …
[HTML][HTML] Diagnosis and biomarkers for ocular tuberculosis: From the present into the future
Z Ludi, AA Sule, RP Samy, I Putera, B Schrijver… - Theranostics, 2023 - ncbi.nlm.nih.gov
Tuberculosis is an airborne disease caused by Mycobacterium tuberculosis (Mtb) and can
manifest both pulmonary and extrapulmonary disease, including ocular tuberculosis (OTB) …
manifest both pulmonary and extrapulmonary disease, including ocular tuberculosis (OTB) …
HLA-DR marks recently divided antigen-specific effector CD4 T cells in active tuberculosis patients
R Tippalagama, A Singhania, P Dubelko… - The Journal of …, 2021 - journals.aai.org
Upon Ag encounter, T cells can rapidly divide and form an effector population, which plays
an important role in fighting acute infections. In humans, little is known about the molecular …
an important role in fighting acute infections. In humans, little is known about the molecular …
Classical CD4 T cells as the cornerstone of antimycobacterial immunity
J Morgan, K Muskat, R Tippalagama… - Immunological …, 2021 - Wiley Online Library
Tuberculosis is a significant health problem without an effective vaccine to combat it. A
thorough understanding of the immune response and correlates of protection is needed to …
thorough understanding of the immune response and correlates of protection is needed to …
Perspective for precision medicine for tuberculosis
Tuberculosis is a bacterial infectious disease that is mainly transmitted from human to
human via infectious aerosols. Currently, tuberculosis is the leading cause of death by an …
human via infectious aerosols. Currently, tuberculosis is the leading cause of death by an …
Disease extent and anti‐tubercular treatment response correlates with Mycobacterium tuberculosis‐specific CD4 T‐cell phenotype regardless of HIV‐1 status
Objectives The development of non‐sputum‐based assays for tuberculosis (TB) diagnosis
and treatment monitoring is a key priority. Recent data indicate that whole blood‐based …
and treatment monitoring is a key priority. Recent data indicate that whole blood‐based …
CD38+CD27–TNF-α + on Mtb-specific CD4+ T Cells Is a Robust Biomarker for Tuberculosis Diagnosis
MP Acharya, SP Pradeep, VS Murthy… - Clinical Infectious …, 2021 - academic.oup.com
Background Early and accurate diagnosis followed by timely treatment are the key
prerequisites to fight tuberculosis (TB) and reduce its global burden. Despite scientific …
prerequisites to fight tuberculosis (TB) and reduce its global burden. Despite scientific …