Ovarian cancer is the fifth cause of cancer-related death in women and comprises a
histologically and genetically broad range of tumours, including those of epithelial, sex cord …

Mortality from ovarian cancer may be dramatically reduced with the implementation of
attainable prevention strategies. The new understanding of the cells of origin and the …

Internationally, ovarian cancer is the 7th leading cancer diagnosis and 8th leading cause of
cancer mortality among women. Ovarian cancer incidence varies by region, particularly …

Patients with ovarian cancer usually present with advanced disease, and the disease is
generally managed with surgical resection followed by platinum-based chemotherapy …

Background Data concerning the efficacy of bilateral prophylactic oophorectomy for
reducing the risk of gynecologic cancer in women with BRCA1 or BRCA2 mutations are …

Background Oral contraceptives were introduced almost 50 years ago, and over 100 million
women currently use them. Oral contraceptives can reduce the risk of ovarian cancer, but the …

BACKGROUND: The heritable fraction of ovarian cancer exceeds that of any other common
adult cancer. Most inherited cases of ovarian cancer are due to a germline mutation in …

BACKGROUND It is believed that BRCA1 and BRCA2 germline mutations account for the
majority of hereditary ovarian carcinomas; however, to the authors' knowledge, there are …

Cancer genetics is increasingly becoming integrated into the practice of modern medical
oncology. The ability to distinguish a growing proportion of the 5% to 10% of all cancers that …

Background: BRCA1 and BRCA2 mutations in general populations and in various types of
cancers have not been well characterized. We investigated the presence of these mutations …