The role of the gut microbiome in diabetes and obesity-related kidney disease
A Zaky, SJ Glastras, MYW Wong, CA Pollock… - International journal of …, 2021 - mdpi.com
Diabetic kidney disease (DKD) is a progressive disorder, which is increasing globally in
prevalence due to the increased incidence of obesity and diabetes mellitus. Despite optimal …
prevalence due to the increased incidence of obesity and diabetes mellitus. Despite optimal …
[HTML][HTML] The role of innate immunity in diabetic nephropathy and their therapeutic consequences
M Yang, C Zhang - Journal of Pharmaceutical Analysis, 2024 - Elsevier
Diabetic nephropathy (DN) is an enduring condition that leads to inflammation and affects a
substantial number of individuals with diabetes worldwide. A gradual reduction in …
substantial number of individuals with diabetes worldwide. A gradual reduction in …
Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects
OBJECTIVE Individuals with type 2 diabetes have a myriad of metabolic aberrations
including increased inflammation, increasing their cardiovascular risk. Toll-like receptors …
including increased inflammation, increasing their cardiovascular risk. Toll-like receptors …
High glucose induces toll-like receptor expression in human monocytes: mechanism of activation
OBJECTIVE—Hyperglycemia-induced inflammation is central in diabetes complications,
and monocytes are important in orchestrating these effects. Toll-like receptors (TLRs) play a …
and monocytes are important in orchestrating these effects. Toll-like receptors (TLRs) play a …
Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state
Abstract Context: Type 1 diabetes (T1DM) is associated with increased cardiovascular
mortality. It is a pro-inflammatory state as evidenced by increased circulating biomarkers and …
mortality. It is a pro-inflammatory state as evidenced by increased circulating biomarkers and …
Modulation of three key innate immune pathways for the most common retinal degenerative diseases
This review highlights the role of three key immune pathways in the pathophysiology of
major retinal degenerative diseases including diabetic retinopathy, age‐related macular …
major retinal degenerative diseases including diabetic retinopathy, age‐related macular …
Impact of systemic inflammation on the progression of gestational diabetes mellitus
T Lekva, ER Norwitz, P Aukrust, T Ueland - Current diabetes reports, 2016 - Springer
With increasing rates of obesity and new diagnostic criteria for gestational diabetes mellitus
(GDM), the overall prevalence of GDM is increasing worldwide. Women with GDM have an …
(GDM), the overall prevalence of GDM is increasing worldwide. Women with GDM have an …
[HTML][HTML] Targeting neuroinflammation in distal symmetrical polyneuropathy in diabetes
ZZ Chong, DL Menkes, N Souayah - Drug discovery today, 2024 - Elsevier
Diabetic distal symmetric polyneuropathy is the most common type of peripheral neuropathy
complication of diabetes mellitus. Neuroinflammation is emerging as an important …
complication of diabetes mellitus. Neuroinflammation is emerging as an important …
[HTML][HTML] Diabetic retinopathy and dysregulated innate immunity
Diabetic retinopathy (DR) is the progressive degeneration of retinal blood vessels and
neurons. Inflammation is known to play an important role in the pathogenesis of DR. During …
neurons. Inflammation is known to play an important role in the pathogenesis of DR. During …
Blood-based DNA methylation biomarkers for type 2 diabetes: potential for clinical applications
Type 2 diabetes (T2D) is a leading cause of death and disability worldwide. It is a chronic
metabolic disorder that develops due to an interplay of genetic, lifestyle, and environmental …
metabolic disorder that develops due to an interplay of genetic, lifestyle, and environmental …