Curcumin as an antiviral agent

MR Jennings, RJ Parks - Viruses, 2020 - mdpi.com
Curcumin, the primary curcuminoid compound found in turmeric spice, has shown broad
activity as an antimicrobial agent, limiting the replication of many different fungi, bacteria and …

The relationship between sex hormones, the vaginal microbiome and immunity in HIV-1 susceptibility in women

JM Wessels, AM Felker, HA Dupont… - Disease models & …, 2018 - journals.biologists.com
The role of sex hormones in regulating immune responses in the female genital tract has
been recognized for decades. More recently, it has become increasingly clear that sex …

[HTML][HTML] Vaginal lactic acid elicits an anti-inflammatory response from human cervicovaginal epithelial cells and inhibits production of pro-inflammatory mediators …

AC Hearps, D Tyssen, D Srbinovski, L Bayigga… - Mucosal …, 2017 - Elsevier
Inflammation in the female reproductive tract (FRT) is associated with increased HIV
transmission. Lactobacillus spp. dominate the vaginal microbiota of many women and their …

HIV-1 gp120 induces TLR2-and TLR4-mediated innate immune activation in human female genital epithelium

A Nazli, JK Kafka, VH Ferreira, V Anipindi… - The Journal of …, 2013 - journals.aai.org
Although women constitute half of all HIV-1–infected people worldwide (UNAIDS World
AIDS Day Report, 2011), the earliest events in the female reproductive tract (FRT) during …

The anti-inflammatory activity of curcumin protects the genital mucosal epithelial barrier from disruption and blocks replication of HIV-1 and HSV-2

VH Ferreira, A Nazli, SE Dizzell, K Mueller, C Kaushic - PloS one, 2015 - journals.plos.org
Inflammation is a known mechanism that facilitates HIV acquisition and the spread of
infection. In this study, we evaluated whether curcumin, a potent and safe anti-inflammatory …

Innate and adaptive immune responses in male and female reproductive tracts in homeostasis and following HIV infection

PV Nguyen, JK Kafka, VH Ferreira, K Roth… - Cellular & molecular …, 2014 - nature.com
The male and female reproductive tracts are complex microenvironments that have diverse
functional demands. The immune system in the reproductive tract has the demanding task of …

Curcumin can decrease tissue inflammation and the severity of HSV-2 infection in the female reproductive mucosa

D Vitali, P Bagri, JM Wessels, M Arora… - International Journal of …, 2020 - mdpi.com
Herpes Simplex Virus Type 2 (HSV-2) is one of the most prevalent sexually transmitted
viruses and is a known risk factor for HIV acquisition in the Female Genital Tract (FGT) …

Neisseria gonorrhoeae-derived heptose elicits an innate immune response and drives HIV-1 expression

RJ Malott, BO Keller, RG Gaudet… - Proceedings of the …, 2013 - National Acad Sciences
Clinical and epidemiological synergy exists between the globally important sexually
transmitted infections, gonorrhea and HIV. Neisseria gonorrhoeae, which causes gonorrhea …

Interplay between viruses and bacterial microbiota in cancer development

D Vyshenska, KC Lam, N Shulzhenko… - Seminars in immunology, 2017 - Elsevier
During the last few decades we have become accustomed to the idea that viruses can cause
tumors. It is much less considered and discussed, however, that most people infected with …

Cervical intraepithelial neoplasia is associated with genital tract mucosal inflammation

M Mhatre, T McAndrew, C Carpenter… - Sexually transmitted …, 2012 - journals.lww.com
Background: Clinical studies demonstrate increased prevalence of human papillomavirus
(HPV)-associated disease in HIV-infected individuals and an increased risk of HIV …