Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
The brain requires a continuous supply of energy in the form of ATP, most of which is
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …
[HTML][HTML] Mitochondrial (dys) function and insulin resistance: from pathophysiological molecular mechanisms to the impact of diet
Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance, the
hallmark of type 2 diabetes mellitus (T2DM). However, the cause-effect relationship remains …
hallmark of type 2 diabetes mellitus (T2DM). However, the cause-effect relationship remains …
Light modulates glucose metabolism by a retina-hypothalamus-brown adipose tissue axis
Public health studies indicate that artificial light is a high-risk factor for metabolic disorders.
However, the neural mechanism underlying metabolic modulation by light remains elusive …
However, the neural mechanism underlying metabolic modulation by light remains elusive …
Effects of dietary restriction on neuroinflammation in neurodegenerative diseases
Recent and accumulating work in experimental animal models and humans shows that diet
has a much more pervasive and prominent role than previously thought in modulating …
has a much more pervasive and prominent role than previously thought in modulating …
Role of nitric oxide in insulin secretion and glucose metabolism
Nitric oxide (NO) contributes to carbohydrate metabolism and decreased NO bioavailability
is involved in the development of type 2 diabetes mellitus (T2DM). NO donors may improve …
is involved in the development of type 2 diabetes mellitus (T2DM). NO donors may improve …
[HTML][HTML] Metabolic syndrome, cognitive impairment and the role of diet: a narrative review
Background: This narrative review presents the association between metabolic syndrome
(MetS), along with its components, and cognition-related disorders, as well as the potential …
(MetS), along with its components, and cognition-related disorders, as well as the potential …
[HTML][HTML] The molecular mechanisms underlying mitochondria-associated endoplasmic reticulum membrane-induced insulin resistance
H Cheng, X Gang, G He, Y Liu, Y Wang… - Frontiers in …, 2020 - frontiersin.org
Mitochondria and the endoplasmic reticulum (ER) are connected at multiple sites via what
are known as mitochondria-associated ER membranes (MAMs). These associations are …
are known as mitochondria-associated ER membranes (MAMs). These associations are …
[HTML][HTML] Glucagon's metabolic action in health and disease
Discovered almost simultaneously with insulin, glucagon is a pleiotropic hormone with
metabolic action that goes far beyond its classical role to increase blood glucose. Albeit best …
metabolic action that goes far beyond its classical role to increase blood glucose. Albeit best …
[HTML][HTML] Integrative biology of extracellular vesicles in diabetes mellitus and diabetic complications
J Liu, Y Zhang, Y Tian, W Huang, N Tong, X Fu - Theranostics, 2022 - ncbi.nlm.nih.gov
Diabetes mellitus (DM) is a chronic systemic disease with increasing prevalence globally.
An important aspect of diabetic pathogenesis is cellular crosstalk and information exchange …
An important aspect of diabetic pathogenesis is cellular crosstalk and information exchange …
Prediabetes is associated with structural brain abnormalities: the Maastricht Study
MJM Van Agtmaal, AJHM Houben, V De Wit… - Diabetes …, 2018 - Am Diabetes Assoc
OBJECTIVE Structural brain abnormalities are key risk factors for brain diseases, such as
dementia, stroke, and depression, in type 2 diabetes. It is unknown whether structural brain …
dementia, stroke, and depression, in type 2 diabetes. It is unknown whether structural brain …