The role of brain vasculature in neurodegenerative disorders

MD Sweeney, K Kisler, A Montagne, AW Toga… - Nature …, 2018 - nature.com
Adequate supply of blood and structural and functional integrity of blood vessels are key to
normal brain functioning. On the other hand, cerebral blood flow shortfalls and blood–brain …

Early diagnosis of Alzheimer's disease: the role of biomarkers including advanced EEG signal analysis. Report from the IFCN-sponsored panel of experts

PM Rossini, R Di Iorio, F Vecchio, M Anfossi… - Clinical …, 2020 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disease among the
elderly with a progressive decline in cognitive function significantly affecting quality of life …

Neuroimaging and machine learning for dementia diagnosis: recent advancements and future prospects

MR Ahmed, Y Zhang, Z Feng, B Lo… - IEEE reviews in …, 2018 - ieeexplore.ieee.org
Dementia, a chronic and progressive cognitive declination of brain function caused by
disease or impairment, is becoming more prevalent due to the aging population. A major …

[HTML][HTML] FDG-PET and CSF biomarker accuracy in prediction of conversion to different dementias in a large multicentre MCI cohort

SP Caminiti, T Ballarini, A Sala, C Cerami, L Presotto… - NeuroImage: Clinical, 2018 - Elsevier
Background/aims In this multicentre study in clinical settings, we assessed the accuracy of
optimized procedures for FDG-PET brain metabolism and CSF classifications in predicting …

Amyloid‐β PET in Alzheimer's disease: A systematic review and Bayesian meta‐analysis

D Ruan, L Sun - Brain and Behavior, 2023 - Wiley Online Library
Background In recent years, longitudinal studies of Alzheimer's disease (AD) have been
successively concluded. Our aim is to determine the efficacy of amyloid‐β (Aβ) PET in …

Sum of boxes of the clinical dementia rating scale highly predicts conversion or reversion in predementia stages

RC Tzeng, YW Yang, KC Hsu, HT Chang… - Frontiers in Aging …, 2022 - frontiersin.org
Background The clinical dementia rating (CDR) scale is commonly used to diagnose
dementia due to Alzheimer's disease (AD). The sum of boxes of the CDR (CDR-SB) has …

Brain molecular connectivity in neurodegenerative diseases: recent advances and new perspectives using positron emission tomography

A Sala, D Perani - Frontiers in neuroscience, 2019 - frontiersin.org
Positron emission tomography (PET) represents a unique molecular tool to get in vivo
access to a wide spectrum of biological and neuropathological processes, of crucial …

Brain glucose metabolism in Lewy body dementia: implications for diagnostic criteria

SP Caminiti, A Sala, L Iaccarino, L Beretta… - Alzheimer's research & …, 2019 - Springer
Abstract Background [18F] FDG-PET hypometabolism patterns are indicative of different
neurodegenerative conditions, even from the earliest disease phase. This makes [18F] FDG …

GLP-1 receptor agonists in neurodegeneration: neurovascular unit in the spotlight

G Monti, D Gomes Moreira, M Richner, HAM Mutsaers… - Cells, 2022 - mdpi.com
Defects in brain energy metabolism and proteopathic stress are implicated in age-related
degenerative neuronopathies, exemplified by Alzheimer's disease (AD) and Parkinson's …

Predicting Alzheimer's disease conversion from mild cognitive impairment using an extreme learning machine-based grading method with multimodal data

W Lin, Q Gao, J Yuan, Z Chen, C Feng… - Frontiers in aging …, 2020 - frontiersin.org
Identifying patients with mild cognitive impairment (MCI) who are at high risk of progressing
to Alzheimer's disease (AD) is crucial for early treatment of AD. However, it is difficult to …