Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

The growing field of immune metabolism has revealed promising indications for metabolic
targets to modulate anti-cancer immunity. Combination therapies involving metabolic …

Proliferating cells exhibit a metabolic phenotype known as" aerobic glycolysis," which is
characterized by an elevated rate of glucose fermentation to lactate irrespective of oxygen …

A hallmark of metastasis is the adaptation of tumor cells to new environments. Metabolic
constraints imposed by the serine and glycine–limited brain environment restrict metastatic …

This article presents a personal and critical review of the history of the malate–aspartate
shuttle (MAS), starting in 1962 and ending in 2020. The MAS was initially proposed as a …

De novo pyrimidine biosynthesis is achieved by cytosolic carbamoyl-phosphate synthetase
II, aspartate transcarbamylase and dihydroorotase (CAD) and uridine 5′-monophosphate …

Oncogenic Kras-activated pancreatic ductal adenocarcinoma (PDAC) cells highly rely on an
unconventional glutamine catabolic pathway to sustain cell growth. However, little is known …

Metabolism has been studied mainly in cultured cells or at the level of whole tissues or
whole organisms in vivo. Consequently, our understanding of metabolic heterogeneity …

L-aspartate (Asp) serves as a central building block, in addition to being a constituent of
proteins, for many metabolic processes in most organisms, such as biosynthesis of other …

Numerous mechanisms to support cells under conditions of transient nutrient starvation
have been described. Several functions of the tumor-suppressor protein p53 can contribute …