Integrin receptors are the main molecular link between cells and the extracellular matrix
(ECM) as well as mediating cell–cell interactions. Integrin–ECM binding triggers the …

In addition to biochemical signals and genetic considerations, mechanical forces are rapidly
emerging as a master regulator of human physiology. However, the molecular mechanisms …

The sites of interaction between a cell and its surrounding microenvironment serve as
dynamic signaling hubs that regulate cellular adaptations during developmental processes …

Talin and vinculin are part of a multicomponent system involved in mechanosensing in cell-
matrix adhesions. Both exist in autoinhibited forms, and activation of vinculin requires …

In solid tumours, cancer cells that undergo epithelial mesenchymal transition (EMT) express
characteristic gene expression signatures that promote invasive migration as well as the …

Talins are cytoskeletal linker proteins that consist of an N-terminal head domain, a flexible
neck region and a C-terminal rod domain made of 13 helical bundles. The head domain …

The Mercator projection map of the world provides a useful, but distorted, view of the relative
scale of countries. Current cellular models suffer from a similar distortion. Here, we …

Protein kinase A (PKA) is a ubiquitous, promiscuous kinase whose activity is specified
through subcellular localization mediated by A-kinase anchoring proteins (AKAPs). PKA has …

Cells sense and respond to subtle changes in their physicality, and via a myriad of different
mechanosensitive processes, convert these physical cues into chemical and biochemical …

Research over the past two decades has highlighted that mechanical signaling is a crucial
component in regulating biological processes. Although many processes and proteins are …