Conditional gene expression has greatly facilitated the examination of the functions of
particular gene products. Using the Cre/lox P switching expression system, we plan to …

IgG4-related disease is a newly recognized fibro-inflammatory condition characterized by
several features: a tendency to form tumefactive lesions in multiple sites; a characteristic …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

Cryptic MHC I-associated peptides (MAPs) are produced via two mechanisms: translation of
protein-coding genes in non-canonical reading frames and translation of allegedly non …

The recent discovery of fusion of endoplasmic reticulum membrane with nascent
phagosomes suggests that this peripheral compartment in macrophages and dendritic cells …

BACKGROUND: Pancreatic ductal adenocarcinoma represents 90% of pancreatic cancers
and is an important cause of cancer death in the United States. Operative resection remains …

Conventionally, MHC class I-restricted antigen (Ag) processing requires the action of the
multimolecular peptide-loading complex within the endoplasmic reticulum (ER). Here we …

The loading of MHC class I molecules with their peptide cargo is undertaken by a
multimolecular peptide loading complex within the endoplasmic reticulum. We show that …

Loading of MHC-I molecules with peptide by the catalytic chaperone tapasin in the peptide
loading complex plays a critical role in antigen presentation and immune recognition …

Peptide binding to major histocompatibility complex (MHC) dass I molecules occurs in the
endoplasmic reticulum (ER). Efficient peptide binding requires a number of components in …