Ovarian cancer encompasses a heterogeneous group of malignancies that involve the
ovaries, fallopian tubes and the peritoneal cavity. Despite major advances made within the …

Ovarian cancer (OC) is one of the most common gynecological malignancies with high
morbidity and mortality. The peritoneum is one of the most common metastatic sites in …

Murine tissues harbor signature γδ T cell compartments with profound yet differential
impacts on carcinogenesis. Conversely, human tissue-resident γδ cells are less well …

Gamma delta T (γδ T) cells are among the most potent cytotoxic lymphocytes. Activating anti–
butyrophilin 3A (BTN3A) antibodies prime diverse tumor cell types to be killed by Vγ9Vδ2 T …

Gamma delta (γδ) T cells reside within human tissues including tumors, but their function in
mediating antitumor responses to immune checkpoint inhibition is unknown. Here we show …

Checkpoint inhibition (CPI), particularly that targeting the inhibitory coreceptor programmed
cell death protein 1 (PD-1), has transformed oncology. Although CPI can derepress cancer …

While the effector cells that mediate anti-tumor immunity have historically been attributed to
αβ T cells and natural killer cells, γδ T cells are now being recognized as a complementary …

Phenotypic characterization of γδ T cells in the MALs (malignant ascites lymphocytes), TILs
(tumor infiltrating lymphocytes), and PBLs (peripheral blood lymphocytes) of ovarian cancer …

Patients with type 2 diabetes mellitus (T2DM) have an increased risk of cancer. The effect of
glucose metabolism on γδ T cells and their impact on tumor surveillance remain unknown …

Ovarian cancer is a less common tumor in women compared to cervical or breast cancer,
however it is more malignant and has worse outcomes. Ovarian cancer patients still have a …