Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …

The intricate pathophysiology of brain disorders, difficult access to the brain, and the
complexity and high risks and costs of drug development represent major hurdles for …

Background The presence of calcitonin gene-related peptide and its receptors in multiple
brain areas and peripheral tissues previously implicated in migraine initiation and its many …

Objective To evaluate the efficacy and safety of AVP‐825, a drug–device combination of low‐
dose sumatriptan powder (22 mg loaded dose) delivered intranasally through a targeted B …

Cortical spreading depression (CSD) is a wave of neuronal depolarization thought to
underlie migraine aura. Calcitonin gene-related peptide (CGRP) is a potent vasodilator …

Trigeminal autonomic cephalalgias are highly disabling primary headache disorders,
characterized by severe unilateral head pain and associated ipsilateral cranial autonomic …

Migraine headache and its associated symptoms have plagued humans for two millennia. It
is manifest throughout the world, and affects more than 1/6 of the global population. It is the …

Objective The objective of this study was to compare the efficacy, tolerability, and safety of
AVP‐825, an investigational bi‐directional breath‐powered intranasal delivery system …

Migraine is a common and disabling neurological disorder, with a significant socioeconomic
burden. Its pathophysiology involves abnormalities in complex neuronal networks …