Molecular recognition by proteins is fundamental to molecular biology. Dissection of the
thermodynamic energy terms governing protein–ligand interactions has proven difficult, with …

Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful tool that has enabled
experimentalists to characterize molecular dynamics and kinetics spanning a wide range of …

Amyloid fibril deposits found in Alzheimer disease patients are composed of amyloid-β (Aβ)
protein forming a number of hydrophobic interfaces that are believed to be mostly rigid. We …

LmrR is a multidrug transcriptional repressor that controls the expression of a major
multidrug transporter, LmrCD, in Lactococcus lactis. However, the molecular mechanism by …

Nuclear magnetic resonance (NMR) spin relaxation is the most informative approach to
experimentally probe the internal dynamics of proteins on the picosecond to nanosecond …

Allostery is a regulatory phenomenon whereby ligand binding to one site influences the
binding of the same or a different ligand to another site on a macromolecule. The physical …

Ligands of the transmembrane protein TSPO are used for imaging of brain inflammation, but
a common polymorphism in TSPO complicates their application to humans. Here we …

Nuclear magnetic resonance (NMR) has the unique advantage of elucidating the structure
and dynamics of biomolecules in solution at physiological temperatures, where they are in …

NMR measurements of cross-correlated nuclear spin relaxation provide powerful probes of
polypeptide dynamics and rotational diffusion, free from contributions due to chemical …

Nuclear magnetic resonance (NMR) is a valuable tool for determining the structures of
molecules and probing their dynamics. A longstanding problem facing both small-molecule …