Introduction In order to assess the significance of drug levels measured in intensive care
medicine, clinical and forensic toxicology, as well as for therapeutic drug monitoring, it is …

In order to assess the significance of drug levels measured in clinical and forensic toxicology
as well as for Therapeutic Drug Monitoring (TDM) it is essential that good collections of data …

Intermittent intravenous administration of antibiotics is the first-line approach in the
management of severe infections worldwide. However, the potential benefits of alternate …

Background Intravenous broad–spectrum antibiotics are indicated for the treatment of
severe infections. However, the emergence of infections caused by multiple‐drug resistant …

We performed a systematic review of randomised clinical trials to evaluate the comparative
pharmacokinetic and pharmacodynamic properties of the continuous versus intermittent …

Aims Surgical site infections contribute to morbidity and mortality after surgery. The authors
hypothesized that higher antibiotic tissue concentrations can be reached for a prolonged …

Cephalosporins have traditionally been administered as an intermittent infusion. With the
knowledge that cephalosporins demonstrate a time-dependent pharmacodynamic profile …

OBJECTIVES:: The objective of this study was to determine the pharmacokinetics of
cefuroxime in children undergoing cardiopulmonary bypass (CPB) for cardiovascular …

OBJECTIVE: The objective was to investigate the plasma levels and to compare the
pharmacokinetics of cefuroxime during and after surgery in adult patients with elective …

Cardiopulmonary bypass and hypothermia (HCPB) is a procedure commonly used during
heart surgery, representing a risk factor for the patient by promoting extensive haemodilution …