Reduced synaptic depression in human neurons carrying homozygous disease-causing STXBP1 variant L446F
M Öttl, RF Toonen, M Verhage - Human molecular genetics, 2024 - academic.oup.com
MUNC18-1 is an essential protein of the regulated secretion machinery. De novo,
heterozygous mutations in STXBP1, the human gene encoding this protein, lead to a severe …
heterozygous mutations in STXBP1, the human gene encoding this protein, lead to a severe …
Mapping the endosomal proximity proteome reveals Retromer as a hub for RAB GTPase regulation.
Endosomal retrieval and recycling of integral cargo proteins is essential for cell, tissue and
organism-level development and homeostasis and is orchestrated through a specialised …
organism-level development and homeostasis and is orchestrated through a specialised …
[HTML][HTML] Selecting genes for analysis using historically contingent progress
F Lalit, AM Jose - bioRxiv, 2024 - ncbi.nlm.nih.gov
Progress in biology has generated numerous lists of genes that share some property. But,
advancing from the initial implication of a set of genes in a process to understanding their …
advancing from the initial implication of a set of genes in a process to understanding their …
[HTML][HTML] PPIscreenML: Structure-based screening for protein-protein interactions using AlphaFold
V Mischley, J Maier, J Chen, J Karanicolas - bioRxiv, 2024 - ncbi.nlm.nih.gov
Protein-protein interactions underlie nearly all cellular processes. With the advent of protein
structure prediction methods such as AlphaFold2 (AF2), models of specific protein pairs can …
structure prediction methods such as AlphaFold2 (AF2), models of specific protein pairs can …
Layer-by-Layer Nanoparticles for Cytokine Delivery
IS Pires - 2024 - dspace.mit.edu
In the past decade, cancer immunotherapy has been a promising therapeutic strategy for
cancer treatment. However, immunotherapy has failed to improve responses in certain …
cancer treatment. However, immunotherapy has failed to improve responses in certain …