Multiple sclerosis is a chronic, demyelinating disease of the CNS. Cognitive impairment is a
sometimes neglected, yet common, sign and symptom with a profound effect on instrumental …

Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS,
which can be compared across CNS regions, patients, and centres. In patients with multiple …

Importance Cognitive impairment is a common and disabling feature of multiple sclerosis
(MS), but a precise characterization of cognitive phenotypes in patients with MS is lacking …

Neuropsychiatric abnormalities may be broadly divided in two categories: disorders of
mood, affect, and behavior and abnormalities affecting cognition. Among these conditions …

MRI studies have provided valuable insights into the structure and function of neural
networks, particularly in health and in classical neurodegenerative conditions such as …

Meningeal inflammation strongly associates with demyelination and neuronal loss in the
underlying cortex of progressive MS patients, thereby contributing significantly to clinical …

Inflammatory demyelinating diseases (IDDs) are among the main causes of inflammatory
and neurodegenerative injury of the central nervous system (CNS) in young adult patients …

Background: A limited number of studies investigated associations between serum
neurofilament light chain (sNfL) and cognition in persons with multiple sclerosis (PwMS) …

Background and Objectives There is currently no consensus about the extent of gray matter
(GM) atrophy that can be attributed to secondary changes after white matter (WM) lesions or …

Abstract Machine learning (ML) and its subset, deep learning (DL), are branches of artificial
intelligence (AI) showing promising findings in the medical field, especially when applied to …