Identification of clinically relevant biomarkers of epileptogenesis—a strategic roadmap
M Simonato, DV Agoston, A Brooks-Kayal… - Nature Reviews …, 2021 - nature.com
Onset of many forms of epilepsy occurs after an initial epileptogenic insult or as a result of an
identified genetic defect. Given that the precipitating insult is known, these epilepsies are, in …
identified genetic defect. Given that the precipitating insult is known, these epilepsies are, in …
Clinical relevance of behavior testing in animal models of traumatic brain injury
Traumatic brain injury (TBI) is a leading cause of morbidity worldwide, with patients often
suffering from consequences such as cognitive deficits, social abnormalities, anxiety …
suffering from consequences such as cognitive deficits, social abnormalities, anxiety …
[HTML][HTML] Convolutional neural networks enable robust automatic segmentation of the rat hippocampus in mri after traumatic brain injury
R De Feo, E Hämäläinen, E Manninen… - Frontiers in …, 2022 - frontiersin.org
Registration-based methods are commonly used in the automatic segmentation of magnetic
resonance (MR) brain images. However, these methods are not robust to the presence of …
resonance (MR) brain images. However, these methods are not robust to the presence of …
Imaging biomarkers of posttraumatic epileptogenesis
Traumatic brain injury (TBI) affects 2.5 million people annually within the United States
alone, with over 300 000 severe injuries resulting in emergency room visits and hospital …
alone, with over 300 000 severe injuries resulting in emergency room visits and hospital …
Ratiometric magnetic resonance imaging: Contrast agent design towards better specificity and quantification
N Genicio, M Bañobre-López, O Gröhn… - Coordination Chemistry …, 2021 - Elsevier
Abstract Magnetic Resonance Imaging (MRI) is a powerful imaging tool that combined with
the use of contrast agents (CA) provides meaningful and crucial information both in the …
the use of contrast agents (CA) provides meaningful and crucial information both in the …
Biomarkers for posttraumatic epilepsy
A Pitkänen, T Paananen, J Kyyriäinen, SD Gupta… - Epilepsy & Behavior, 2021 - Elsevier
A biomarker is a characteristic that can be objectively measured as an indicator of normal
biologic processes, pathogenic processes, or responses to an exposure or intervention …
biologic processes, pathogenic processes, or responses to an exposure or intervention …
What value can TSPO PET bring for epilepsy treatment?
V Bouilleret, S Dedeurwaerdere - European Journal of Nuclear Medicine …, 2021 - Springer
Epilepsy is one of the most common neurological disorders and affects both the young and
adult populations. The question we asked for this review was how positron emission …
adult populations. The question we asked for this review was how positron emission …
Image data harmonization tools for the analysis of post-traumatic epilepsy development in preclinical multisite MRI studies
Preclinical MRI studies have been utilized for the discovery of biomarkers that predict post-
traumatic epilepsy (PTE). However, these single site studies often lack statistical power due …
traumatic epilepsy (PTE). However, these single site studies often lack statistical power due …
[HTML][HTML] Brain abscess–A rare confounding factor for diagnosis of post-traumatic epilepsy after lateral fluid-percussion injury
J Kyyriäinen, P Andrade, XE Ndode-Ekane… - Epilepsy Research, 2024 - Elsevier
Objective To assess the prevalence of brain abscesses as a confounding factor for the
diagnosis of post-traumatic epilepsy (PTE) in a rat model of lateral fluid-percussion-induced …
diagnosis of post-traumatic epilepsy (PTE) in a rat model of lateral fluid-percussion-induced …
[HTML][HTML] Minimal specifications for non-human primate MRI: Challenges in standardizing and harmonizing data collection
Recent methodological advances in MRI have enabled substantial growth in neuroimaging
studies of non-human primates (NHPs), while open data-sharing through the PRIME-DE …
studies of non-human primates (NHPs), while open data-sharing through the PRIME-DE …