Identification of clinically relevant biomarkers of epileptogenesis—a strategic roadmap

M Simonato, DV Agoston, A Brooks-Kayal… - Nature Reviews …, 2021 - nature.com
Onset of many forms of epilepsy occurs after an initial epileptogenic insult or as a result of an
identified genetic defect. Given that the precipitating insult is known, these epilepsies are, in …

Clinical relevance of behavior testing in animal models of traumatic brain injury

SR Shultz, SJ McDonald, F Corrigan… - Journal of …, 2020 - liebertpub.com
Traumatic brain injury (TBI) is a leading cause of morbidity worldwide, with patients often
suffering from consequences such as cognitive deficits, social abnormalities, anxiety …

[HTML][HTML] Convolutional neural networks enable robust automatic segmentation of the rat hippocampus in mri after traumatic brain injury

R De Feo, E Hämäläinen, E Manninen… - Frontiers in …, 2022 - frontiersin.org
Registration-based methods are commonly used in the automatic segmentation of magnetic
resonance (MR) brain images. However, these methods are not robust to the presence of …

Imaging biomarkers of posttraumatic epileptogenesis

R Garner, M La Rocca, P Vespa, N Jones, MM Monti… - …, 2019 - Wiley Online Library
Traumatic brain injury (TBI) affects 2.5 million people annually within the United States
alone, with over 300 000 severe injuries resulting in emergency room visits and hospital …

Ratiometric magnetic resonance imaging: Contrast agent design towards better specificity and quantification

N Genicio, M Bañobre-López, O Gröhn… - Coordination Chemistry …, 2021 - Elsevier
Abstract Magnetic Resonance Imaging (MRI) is a powerful imaging tool that combined with
the use of contrast agents (CA) provides meaningful and crucial information both in the …

Biomarkers for posttraumatic epilepsy

A Pitkänen, T Paananen, J Kyyriäinen, SD Gupta… - Epilepsy & Behavior, 2021 - Elsevier
A biomarker is a characteristic that can be objectively measured as an indicator of normal
biologic processes, pathogenic processes, or responses to an exposure or intervention …

What value can TSPO PET bring for epilepsy treatment?

V Bouilleret, S Dedeurwaerdere - European Journal of Nuclear Medicine …, 2021 - Springer
Epilepsy is one of the most common neurological disorders and affects both the young and
adult populations. The question we asked for this review was how positron emission …

Image data harmonization tools for the analysis of post-traumatic epilepsy development in preclinical multisite MRI studies

S Bhagavatula, R Cabeen, NG Harris, O Gröhn… - Epilepsy Research, 2023 - Elsevier
Preclinical MRI studies have been utilized for the discovery of biomarkers that predict post-
traumatic epilepsy (PTE). However, these single site studies often lack statistical power due …

[HTML][HTML] Brain abscess–A rare confounding factor for diagnosis of post-traumatic epilepsy after lateral fluid-percussion injury

J Kyyriäinen, P Andrade, XE Ndode-Ekane… - Epilepsy Research, 2024 - Elsevier
Objective To assess the prevalence of brain abscesses as a confounding factor for the
diagnosis of post-traumatic epilepsy (PTE) in a rat model of lateral fluid-percussion-induced …

[HTML][HTML] Minimal specifications for non-human primate MRI: Challenges in standardizing and harmonizing data collection

JA Autio, Q Zhu, X Li, MF Glasser, CM Schwiedrzik… - NeuroImage, 2021 - Elsevier
Recent methodological advances in MRI have enabled substantial growth in neuroimaging
studies of non-human primates (NHPs), while open data-sharing through the PRIME-DE …