Together with core histones, which make up the nucleosome, the linker histone (H1) is one
of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to …

Post-translational modification (PTM) in histone proteins is a covalent modification which
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …

Histone acetylation is a ubiquitous hallmark of transcription, but whether the link between
histone acetylation and transcription is causal or consequential has not been addressed …

DNA methylation plays a vital role in epigenetic regulation in both plants and animals, and
typically occurs at the 5-carbon position of the cytosine pyrimidine ring within the CpG …

The repeating structural unit of metazoan chromatin is the chromatosome, a nucleosome
bound to a linker histone, H1. There are 11 human H1 isoforms with diverse cellular …

Nucleosomes, the basic structural units of chromatin, hinder recruitment and activity of
various DNA repair proteins, necessitating modifications that enhance DNA accessibility …

The core histone tails are critical in chromatin structure and signaling. Studies over the past
several decades have provided a wealth of information on the histone tails and their …

Information encoded in DNA is interpreted, modified, and propagated as chromatin. The
diversity of inputs encountered by eukaryotic genomes demands a matching capacity for …

Follicular lymphoma (FL) is an indolent malignancy of germinal center B cells. Although the
overall survival of FL patients has recently improved with the introduction of novel therapies …

Nucleosomes and chromatin control eukaryotic genome accessibility and thereby regulate
DNA processes, including transcription, replication, and repair. Conformational dynamics …