Pathophysiology of type 2 diabetes mellitus

U Galicia-Garcia, A Benito-Vicente, S Jebari… - International journal of …, 2020 - mdpi.com
Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused
by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and …

Association between insulin resistance and the development of cardiovascular disease

V Ormazabal, S Nair, O Elfeky, C Aguayo… - Cardiovascular …, 2018 - Springer
For many years, cardiovascular disease (CVD) has been the leading cause of death around
the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid …

American Association of Clinical Endocrinology clinical practice guideline: developing a diabetes mellitus comprehensive care plan—2022 update

L Blonde, GE Umpierrez, SS Reddy, JB McGill… - Endocrine Practice, 2022 - Elsevier
Objective The objective of this clinical practice guideline is to provide updated and new
evidence-based recommendations for the comprehensive care of persons with diabetes …

[HTML][HTML] Current trends in epidemiology of cardiovascular disease and cardiovascular risk management in type 2 diabetes

JS Yun, SH Ko - Metabolism, 2021 - Elsevier
With the advances in diabetes care, the trend of incident cardiovascular disease (CVD) in
patients with type 2 diabetes mellitus (T2DM) has been decreasing over past decades …

The triglyceride glucose index is a simple and low-cost marker associated with atherosclerotic cardiovascular disease: a population-based study

S Hong, K Han, CY Park - BMC medicine, 2020 - Springer
Abstract Background The triglyceride glucose (TyG) index is an inexpensive clinical
surrogate marker for insulin resistance. However, the relationship between TyG index and …

Insulin resistance and atherosclerosis: implications for insulin-sensitizing agents

A Di Pino, RA DeFronzo - Endocrine reviews, 2019 - academic.oup.com
Patients with type 2 diabetes mellitus (T2DM) are at high risk for macrovascular
complications, which represent the major cause of mortality. Despite effective treatment of …

COSMOS-E: guidance on conducting systematic reviews and meta-analyses of observational studies of etiology

OM Dekkers, JP Vandenbroucke, M Cevallos… - PLoS …, 2019 - journals.plos.org
Background To our knowledge, no publication providing overarching guidance on the
conduct of systematic reviews of observational studies of etiology exists. Methods and …

Insulin resistance and hyperglycaemia in cardiovascular disease development

M Laakso, J Kuusisto - Nature Reviews Endocrinology, 2014 - nature.com
The prevalence of diabetes mellitus will likely increase globally from 371 million individuals
in 2013 to 552 million individuals in 2030. This epidemic is mainly attributable to type 2 …

Cardiometabolic-Based Chronic Disease, Adiposity and Dysglycemia Drivers: JACC State-of-the-Art Review

JI Mechanick, ME Farkouh, JD Newman… - Journal of the American …, 2020 - jacc.org
A new cardiometabolic-based chronic disease (CMBCD) model is presented that provides a
basis for early and sustainable, evidence-based therapeutic targeting to promote …

Pioglitazone: the forgotten, cost-effective cardioprotective drug for type 2 diabetes

RA DeFronzo, S Inzucchi… - Diabetes and …, 2019 - journals.sagepub.com
Type 2 diabetes individuals are at high risk for macrovascular complications: myocardial
infarction, stroke and cardiovascular mortality. Recent cardiovascular outcome trials have …