Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …

This review outlines the most frequently used rodent stroke models and discusses their
strengths and shortcomings. Mimicking all aspects of human stroke in one animal model is …

Disorders characterized by ischemia/reperfusion (I/R), such as myocardial infarction, stroke,
and peripheral vascular disease, continue to be among the most frequent causes of …

Understanding amazingly complex brain functions and pathologies requires a complete
cerebral vascular atlas in stereotaxic coordinates. Making a precise atlas for cerebral …

No single animal model is able to encompass all of the variables known to affect human
ischemic stroke. This review highlights the major strengths and weaknesses of the most …

T cells contribute to the pathophysiology of ischemic stroke by yet unknown mechanisms.
Mice with transgenic T-cell receptors (TCRs) and mutations in costimulatory molecules were …

The transcription factor NF-κB is a regulator of cell death or survival. To investigate the role
of NF-κB in neuronal cell death, we studied its activation in a rodent model of stroke. In the …

In experimental animals, as in humans, techniques for measuring blood pressure (BP) have
improved considerably over the past decade. In this document, we present …

Acute neutrophil (PMN) recruitment to postischemic cardiac or pulmonary tissue has
deleterious effects in the early reperfusion period, but the mechanisms and effects of …

We have demonstrated in a previous study that superoxide radicals play a role in the
pathogenesis of cerebral infarction, using a transgenic mouse model of distal middle …