Metal–organic frameworks (MOFs) are versatile compounds with emergent applications in
the fabrication of biosensors for amyloid diseases. They hold great potential in biospecimen …

Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disorder. AD is a
complex and multifactorial disease that is responsible for 60–80% of dementia cases. Aging …

Summary Background Neurofilament light chain (NfL) is a promising biomarker of active
axonal injury and neuronal degeneration. We aimed to characterise cross-sectional and …

Background Due to trisomy of chromosome 21 and the resultant extra copy of the amyloid
precursor protein gene, nearly all adults with Down syndrome develop Alzheimer's disease …

Alzheimer disease (AD) is the most common cause of dementia. Biological definitions of AD
are limited to the cerebral burden of amyloid β plaques, neurofibrillary pathology, and …

Background Neuroimaging studies of autosomal dominant Alzheimer's disease (ADAD)
enable characterization of the trajectories of cerebral amyloid-β (Aβ) and tau accumulation …

γ-Secretase (GS) is an intramembrane aspartyl protease that participates in the sequential
cleavage of C99 to generate different isoforms of the amyloid-β (Aβ) peptides that are …

Introduction Plasma‐measured tau phosphorylated at threonine 217 (p‐tau217) is a
potential non‐invasive biomarker of Alzheimer's disease (AD). We investigated whether …

Importance Recent studies have suggested that unawareness, or anosognosia, of memory
decline is present in predementia stages of Alzheimer disease (AD) and may serve as an …

Introduction Both late-onset Alzheimer's disease (AD) and ageing have a strong genetic
component. In each case, many associated variants have been discovered, but how much …