Understanding the potential role of nanotechnology in liver fibrosis: a paradigm in therapeutics
The liver is a vital organ that plays a crucial role in the physiological operation of the human
body. The liver controls the body's detoxification processes as well as the storage and …
body. The liver controls the body's detoxification processes as well as the storage and …
[HTML][HTML] Advances in the research of nanodrug delivery system for targeted treatment of liver fibrosis
W Peng, S Cheng, Z Bao, Y Wang, W Zhou… - Biomedicine & …, 2021 - Elsevier
Liver fibrosis is one of the major threats to human health. At present, anti-liver fibrosis drugs
exist some problems, such as, lack of targeting, limited treatment effect and more or less …
exist some problems, such as, lack of targeting, limited treatment effect and more or less …
Luteolin-loaded exosomes derived from bone marrow mesenchymal stem cells: a promising therapy for liver fibrosis
Liver fibrosis is a global life-threatening disorder with no approved treatment. It leads to
serious hepatic complications when progressive, such as cirrhosis and carcinoma. Luteolin …
serious hepatic complications when progressive, such as cirrhosis and carcinoma. Luteolin …
Carbon Nitride‐Based siRNA Vectors with Self‐Produced O2 Effects for Targeting Combination Therapy of Liver Fibrosis via HIF‐1α‐Mediated TGF‐β1/Smad …
MX Liu, L Xu, YT Cai, RJ Wang, YY Gu… - Advanced …, 2023 - Wiley Online Library
Hypoxia is an important feature, which can upregulate the hypoxia‐inducible factor‐1α (HIF‐
1α) expression and promote the activation of hepatic stellate cells (HSCs), leading to liver …
1α) expression and promote the activation of hepatic stellate cells (HSCs), leading to liver …
Oral genistein-loaded phytosomes with enhanced hepatic uptake, residence and improved therapeutic efficacy against hepatocellular carcinoma
Genistein (Gen) is one of the most potent soy isoflavones used for hepatocellular carcinoma
(HCC) treatment. Low aqueous solubility and first-pass metabolism are the main obstacles …
(HCC) treatment. Low aqueous solubility and first-pass metabolism are the main obstacles …
Brain-targeted delivery of Valsartan using solid lipid nanoparticles labeled with Rhodamine B; a promising technique for mitigating the negative effects of stroke
The brain is a vital organ that is protected from the general circulation and is distinguished
by the presence of a relatively impermeable blood brain barrier (BBB). Blood brain barrier …
by the presence of a relatively impermeable blood brain barrier (BBB). Blood brain barrier …
Recent advances in nanomedicine for the diagnosis and therapy of liver fibrosis
X Bai, G Su, S Zhai - Nanomaterials, 2020 - mdpi.com
Liver fibrosis, a reversible pathological process of inflammation and fiber deposition caused
by chronic liver injury and can cause severe health complications, including liver failure …
by chronic liver injury and can cause severe health complications, including liver failure …
Synthesis and preparation of vitamin A coupled butein-loaded solid lipid nanoparticles for liver fibrosis therapy in rats
The development of a therapeutic system for hepatic fibrosis has become a research hotspot
to date. Butein, a simple chalcone derivative, displays anti-fibrotic effects through different …
to date. Butein, a simple chalcone derivative, displays anti-fibrotic effects through different …
Valsartan as a prophylactic treatment against breast cancer development and niche activation: What molecular sequels follow chronic AT-1R blockade?
Aims Transactivation of insulin-growth-factor-receptor (IGF-1R) by angiotensin-II-type-1-
receptor (AT-1R) was only demonstrated in vascular-smooth-muscle cells and has never …
receptor (AT-1R) was only demonstrated in vascular-smooth-muscle cells and has never …
Pentoxifylline/Valsartan co-delivery in liposomal gel alters the inflammatory HMGB-1/TLR pathway and promotes faster healing in burn wounds: A promising …
Burn wounds are one of the most severe complex forms of trauma. Hence, new treatment
strategies that facilitate the healing process; reduce the severity and the healing time is the …
strategies that facilitate the healing process; reduce the severity and the healing time is the …