Sepsis exacerbates Alzheimer's disease pathophysiology, modulates the gut microbiome, increases neuroinflammation and amyloid burden

VV Giridharan, CSG Catumbela, CHR Catalão… - Molecular …, 2023 - nature.com
While our understanding of the molecular biology of Alzheimer's disease (AD) has grown,
the etiology of the disease, especially the involvement of peripheral infection, remains a …

Advances in pathogenesis and treatment of vascular endothelial injury-related diseases mediated by mitochondrial abnormality

B Pang, G Dong, T Pang, X Sun, X Liu, Y Nie… - Frontiers in …, 2024 - frontiersin.org
Vascular endothelial cells, serving as a barrier between blood and the arterial wall, play a
crucial role in the early stages of the development of atherosclerosis, cardiovascular …

CBX4 counteracts cellular senescence to desensitize gastric cancer cells to chemotherapy by inducing YAP1 SUMOylation

Y Gu, T Xu, Y Fang, J Shao, T Hu, X Wu, H Shen… - Drug Resistance …, 2024 - Elsevier
Aims As our comprehension of the intricate relationship between cellular senescence and
tumor biology continues to evolve, the therapeutic potential of cellular senescence is gaining …

Inflammation-activated C/EBPβ mediates high-fat diet-induced depression-like behaviors in mice

Y Li, H Chen, J Wang, J Wang, X Niu… - Frontiers in Molecular …, 2022 - frontiersin.org
Depression, one of the most common causes of disability, has a high prevalence rate in
patients with metabolic syndrome. Type 2 diabetes patients are at an increased risk for …

C/EBPβ: A transcription factor associated with the irreversible progression of Alzheimer's disease

Q Yao, C Long, P Yi, G Zhang, W Wan… - CNS Neuroscience …, 2024 - Wiley Online Library
Background Alzheimer's disease (AD) is a neurodegenerative disorder distinguished by a
swift cognitive deterioration accompanied by distinctive pathological hallmarks such as …

Zexieyin formula alleviates atherosclerosis with cognitive impairment: A novel role in the treatment of comorbidities and its underlying mechanisms

Y Sun, H Zhang, R Liu, S Xing, R Huang, D Di… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevancy Zexieyin formula (ZXYF) has been identified to have
therapeutic actions of atherosclerosis (AS). It's unknown that whether ZXYF has therapeutic …

A TrkB cleavage fragment in hippocampus promotes Depressive-Like behavior in mice

J Wang, H Yu, X Li, F Li, H Chen, X Zhang… - Brain, Behavior, and …, 2024 - Elsevier
Decreased hippocampal tropomyosin receptor kinase B (TrkB) level is implicated in the
pathophysiology of stress-induced mood disorder and cognitive decline. However, how TrkB …

Involvement of Fgf2-mediated tau protein phosphorylation in cognitive deficits induced by sevoflurane in aged rats

X Xie, X Zhang, S Li, W Du - Molecular Medicine, 2024 - Springer
Objective Anesthetics have been linked to cognitive alterations, particularly in the elderly.
The current research delineates how Fibroblast Growth Factor 2 (Fgf2) modulates tau …

Meta‐analysis and transcriptomic analysis reveal that NKRF and ZBTB17 regulate the NF‐κB signaling pathway, contributing to the shared molecular mechanisms of …

D Zhang, K Chen, LS Shan - CNS Neuroscience & …, 2024 - Wiley Online Library
Introduction Alzheimer's disease (AD) and atherosclerosis (AS) are widespread diseases
predominantly observed in the elderly population. Despite their prevalence, the underlying …

Chloride intracellular channel 4 blockade improves cognition in mice with Alzheimer's disease: CLIC4 protein expression and tau protein hyperphosphorylation

R Chen, C Pan, X Mao, Y Zhang, G Chen, M Xu… - International Journal of …, 2024 - Elsevier
Numerous academic literature suggests that amyloid-β (Aβ) deposition, tau protein
phosphorylation, and irreversible neuronal death are the three major causes of AD. The …