Sepsis exacerbates Alzheimer's disease pathophysiology, modulates the gut microbiome, increases neuroinflammation and amyloid burden
While our understanding of the molecular biology of Alzheimer's disease (AD) has grown,
the etiology of the disease, especially the involvement of peripheral infection, remains a …
the etiology of the disease, especially the involvement of peripheral infection, remains a …
Advances in pathogenesis and treatment of vascular endothelial injury-related diseases mediated by mitochondrial abnormality
B Pang, G Dong, T Pang, X Sun, X Liu, Y Nie… - Frontiers in …, 2024 - frontiersin.org
Vascular endothelial cells, serving as a barrier between blood and the arterial wall, play a
crucial role in the early stages of the development of atherosclerosis, cardiovascular …
crucial role in the early stages of the development of atherosclerosis, cardiovascular …
CBX4 counteracts cellular senescence to desensitize gastric cancer cells to chemotherapy by inducing YAP1 SUMOylation
Y Gu, T Xu, Y Fang, J Shao, T Hu, X Wu, H Shen… - Drug Resistance …, 2024 - Elsevier
Aims As our comprehension of the intricate relationship between cellular senescence and
tumor biology continues to evolve, the therapeutic potential of cellular senescence is gaining …
tumor biology continues to evolve, the therapeutic potential of cellular senescence is gaining …
Inflammation-activated C/EBPβ mediates high-fat diet-induced depression-like behaviors in mice
Depression, one of the most common causes of disability, has a high prevalence rate in
patients with metabolic syndrome. Type 2 diabetes patients are at an increased risk for …
patients with metabolic syndrome. Type 2 diabetes patients are at an increased risk for …
C/EBPβ: A transcription factor associated with the irreversible progression of Alzheimer's disease
Q Yao, C Long, P Yi, G Zhang, W Wan… - CNS Neuroscience …, 2024 - Wiley Online Library
Background Alzheimer's disease (AD) is a neurodegenerative disorder distinguished by a
swift cognitive deterioration accompanied by distinctive pathological hallmarks such as …
swift cognitive deterioration accompanied by distinctive pathological hallmarks such as …
Zexieyin formula alleviates atherosclerosis with cognitive impairment: A novel role in the treatment of comorbidities and its underlying mechanisms
Y Sun, H Zhang, R Liu, S Xing, R Huang, D Di… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevancy Zexieyin formula (ZXYF) has been identified to have
therapeutic actions of atherosclerosis (AS). It's unknown that whether ZXYF has therapeutic …
therapeutic actions of atherosclerosis (AS). It's unknown that whether ZXYF has therapeutic …
A TrkB cleavage fragment in hippocampus promotes Depressive-Like behavior in mice
Decreased hippocampal tropomyosin receptor kinase B (TrkB) level is implicated in the
pathophysiology of stress-induced mood disorder and cognitive decline. However, how TrkB …
pathophysiology of stress-induced mood disorder and cognitive decline. However, how TrkB …
Involvement of Fgf2-mediated tau protein phosphorylation in cognitive deficits induced by sevoflurane in aged rats
X Xie, X Zhang, S Li, W Du - Molecular Medicine, 2024 - Springer
Objective Anesthetics have been linked to cognitive alterations, particularly in the elderly.
The current research delineates how Fibroblast Growth Factor 2 (Fgf2) modulates tau …
The current research delineates how Fibroblast Growth Factor 2 (Fgf2) modulates tau …
Meta‐analysis and transcriptomic analysis reveal that NKRF and ZBTB17 regulate the NF‐κB signaling pathway, contributing to the shared molecular mechanisms of …
D Zhang, K Chen, LS Shan - CNS Neuroscience & …, 2024 - Wiley Online Library
Introduction Alzheimer's disease (AD) and atherosclerosis (AS) are widespread diseases
predominantly observed in the elderly population. Despite their prevalence, the underlying …
predominantly observed in the elderly population. Despite their prevalence, the underlying …
Chloride intracellular channel 4 blockade improves cognition in mice with Alzheimer's disease: CLIC4 protein expression and tau protein hyperphosphorylation
R Chen, C Pan, X Mao, Y Zhang, G Chen, M Xu… - International Journal of …, 2024 - Elsevier
Numerous academic literature suggests that amyloid-β (Aβ) deposition, tau protein
phosphorylation, and irreversible neuronal death are the three major causes of AD. The …
phosphorylation, and irreversible neuronal death are the three major causes of AD. The …