Natural killer T (NKT) cells are a subset of CD1d-restricted T cells at the interface between
the innate and adaptive immune system. NKT cells can be subdivided into functional …

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▪ Abstract NK cells are regulated by opposing signals from receptors that activate and inhibit
effector function. While positive stimulation may be initiated by an array of co-stimulatory …

KIR genes have evolved in primates to generate a diverse family of receptors with unique
structures that enable them to recognize MHC-class I molecules with locus and allele …

▪ Abstract Major histocompatibility complex class I-specific inhibitory receptors on natural
killer cells prevent the lysis of healthy autologous cells. The outcome of this negative signal …

Recent genetic studies have established that the killer cell immunoglobulin‐like receptor
(KIR) genomic region displays extensive diversity through variation in gene content and …

Cytotoxicity of human NK cells is under negative control of killer cell Ig-like receptors (KIR)
specific for HLA class I. To determine the specificity of five KIR containing two Ig domains …

Natural killer cells express inhibitory receptors specific for MHC class I proteins and
stimulatory receptors with diverse specificities. The MHC-specific receptors discriminate …

Because of its location and function, the liver is continuously exposed to a large antigenic
load that includes pathogens, toxins, tumor cells and harmless dietary antigens. The range …

Unlike primary T cells in lymph nodes, effector CD8+ CTL in tissues do not express the
costimulatory receptor CD28. We report that NKG2D, the receptor for stress-induced MICA …