Zebrafish tools for deciphering habenular network-linked mental disorders

A Bühler, M Carl - Biomolecules, 2021 - mdpi.com
Simple Summary Everything that we think, feel or do depends on the function of neural
networks in the brain. These are highly complex structures made of cells (neurons) and their …

Molecular signatures and cellular diversity during mouse habenula development

LL van de Haar, D Riga, JE Boer, O Garritsen, Y Adolfs… - Cell reports, 2022 - cell.com
The habenula plays a key role in various motivated and pathological behaviors and is
composed of molecularly distinct neuron subtypes. Despite progress in identifying mature …

Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain

GT Powell, A Faro, Y Zhao, H Stickney… - Science, 2024 - science.org
Neurons on the left and right sides of the nervous system often show asymmetric properties,
but how such differences arise is poorly understood. Genetic screening in zebrafish …

Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel

L Michel, K Palma, M Cerda, R Lagadec… - Frontiers in Cell and …, 2022 - frontiersin.org
Habenulae asymmetries are widespread across vertebrates and analyses in zebrafish, the
reference model organism for this process, have provided insight into their molecular nature …

Imaging the radioprotective effect of amifostine in the developing brain using an apoptosis-reporting transgenic zebrafish

LWH Sun, HT Asana Marican, LK Beh… - International Journal of …, 2024 - Taylor & Francis
Purpose Normal tissue radioprotectants alleviate radiation-induced damages and preserve
critical organ functions. Investigating their efficacy in vivo remains challenging, especially in …

Conserved and diverged asymmetric gene expression in the brain of teleosts

C Agostini, A Bühler, A Antico Calderone… - Frontiers in Cell and …, 2022 - frontiersin.org
Morphological left-right brain asymmetries are universal phenomena in animals. These
features have been studied for decades, but the functional relevance is often unclear …

Wnt1 Role in the Development of the Habenula and the Fasciculus Retroflexus

V Company, A Moreno-Cerdá… - Frontiers in Cell and …, 2021 - frontiersin.org
Wnt1 is one of the morphogenes that controls the specification and differentiation of
neuronal populations in the developing central nervous system. The habenula is a …

Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons

V Company, A Andreu-Cervera, MP Madrigal… - Frontiers in Cell and …, 2021 - frontiersin.org
The fasciculus retroflexus is an important fascicle that mediates reward-related behaviors
and is associated with different psychiatric diseases. It is the main habenular efference and …

Analysis of a shark reveals ancient habenular asymmetries in gnathostomes and points to Wnt regulation as a driving force in their diversification

M Lanoizelet, L Michel, R Lagadec, H Mayeur… - bioRxiv, 2023 - biorxiv.org
In order to gain insight into the origin and mode of evolution of asymmetries in the vertebrate
habenula, we have used combinations of transcriptomic and functional approaches in a …

Cachd1 is a novel Frizzled-and LRP6-interacting protein required for neurons to acquire left-right asymmetric character

GT Powell, A Faro, Y Zhao, H Stickney… - BioRxiV, 2022 - biorxiv.org
Neurons on left and right sides of the nervous system frequently show asymmetric properties
but how these differences arise is poorly understood. Through a forward genetic screen in …