Background The poor physical health of people with mental illness is a multifaceted,
transdiagnostic, and global problem. People with mental illness have an increased risk of …

In pragmatic trials, participants are broadly representative of people who will receive a
treatment or diagnostic strategy, and the outcomes affect day-to-day care. The authors …

Background: In FOURIER (Further Cardiovascular Outcomes Research With PCSK9
Inhibition in Subjects With Elevated Risk), the proprotein convertase subtilisin-kexin type 9 …

Background Although coronary computed tomographic angiography (CTA) improves
diagnostic certainty in the assessment of patients with stable chest pain, its effect on 5-year …

Background People with type 1 diabetes are at elevated risk of mortality and cardiovascular
disease, yet current guidelines do not consider age of onset as an important risk stratifier …

Methods The original intervention (mean treatment duration 7.8 years) involved 160 patients
with type 2 diabetes and microalbuminuria who were randomly assigned (using sealed …

Familial hypercholesterolaemia (FH) is a common genetic cause of premature coronary
heart disease (CHD). Globally, one baby is born with FH every minute. If diagnosed and …

Níveis de evidência Nível A Dados obtidos a partir de múltiplos estudos randomizados de
bom porte, concordantes e/ou de meta-análise robusta de estudos clínicos randomizados …

Background Hydroxymethyl glutaryl coenzyme A reductase inhibitors, commonly called
statins, are some of the most commonly prescribed medications worldwide. Evidence …

Background Statins reduce LDL cholesterol and prevent vascular events, but their net effects
in people at low risk of vascular events remain uncertain. Methods This meta-analysis …