Arterial stiffness, a leading marker of risk in hypertension, can be measured at material or
structural levels, with the latter combining effects of the geometry and composition of the …

This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Townsend et al Vascular Research on Arterial Stiffness 699 pressure, blood flow, and
arterial diameter change with each heartbeat. In addition to the passive mechanical …

Pathophysiological studies have extensively investigated the structural factor in
hypertension, including large and small artery remodeling and functional changes. Here, we …

Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Acute kidney injury occurs with kidney transplantation and too frequently progresses to the
clinical diagnosis of delayed graft function (DGF). Poor kidney function in the first week of …

involves 2 different mechanisms. 1 The first is related to the development of a high-pressure
wave by the left ventricle that ejects into the proximal aorta (proximal compartment). The …

Over the past decade, numerous studies have shown that increased aortic stiffness is
associated with major cardiovascular disease end points, including heart disease, stroke …

Unlike the majority of patients with uncomplicated hypertension in whom minimal renal
damage develops in the absence of severe blood pressure (BP) elevations, patients with …

Resting heart rate is central to cardiac output and is influenced by changes occurring in
numerous diseases. It predicts longevity and cardiovascular diseases, and current evidence …