Heart disease is the leading cause of mortality in developed countries. The associated
pathology is characterized by a loss of cardiomyocytes that leads, eventually, to heart failure …

Immunometabolism is an emerging field at the intersection of immunology and metabolism.
Immune cell activation plays a critical role in the pathogenesis of cardiovascular diseases …

Human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) have been
used extensively to model inherited heart diseases, but hiPSC-CM models of ischemic heart …

Members of the fetal-gene-program may act as regulatory components to impede
deleterious events occurring with cardiac remodeling, and constitute potential novel …

Abstract Background Cardiac fibroblasts (CFs) and cardiomyocytes are the major cell
populations in the heart. CFs not only support cardiomyocytes by producing extracellular …

We examine different approaches for the controlled release of L-lactate, which is a signaling
molecule that participates in tissue remodeling and regeneration, such as cardiac and …

Cardiomyocytes rely on specialised metabolism to meet the high energy demand of the
heart. During heart development, metabolism matures and shifts from the predominant …

While largely appreciated for their antimicrobial and repair functions, macrophages have
emerged as indispensable for the development, homeostasis, and regeneration of tissue …

In situ tissue engineering strategies are a promising approach to activate the endogenous
regenerative potential of the cardiac tissue helping the heart to heal itself after an injury …

Nowadays one of the main causes of death is cardiovascular diseases, principally cardiac
failure or myocardial infarction. As a result of these health disorders, scientists, especially …