The chemistry and biological activities of peptides from amphibian skin secretions

X Xu, R Lai - Chemical reviews, 2015 - ACS Publications
Amphibian skin is directly exposed to different environments. Amphibians interact with
environmental factors including microorganisms, parasites, predators, and physical factors …

Rationalizing the membrane interactions of cationic amphipathic antimicrobial peptides by their molecular shape

B Bechinger - Current Opinion in Colloid & Interface Science, 2009 - Elsevier
Biophysical and structural studies of cationic amphipathic antimicrobial peptides have
revealed new mechanistic details concerning their membrane interactions. In interfacial …

DADP: the database of anuran defense peptides

M Novković, J Simunić, V Bojović, A Tossi… - …, 2012 - academic.oup.com
Anuran tissues, and especially skin, are a rich source of bioactive peptides and their
precursors. We here present a manually curated database of antimicrobial and other …

[HTML][HTML] Structure and topology of the huntingtin 1–17 membrane anchor by a combined solution and solid-state NMR approach

M Michalek, ES Salnikov, B Bechinger - Biophysical journal, 2013 - cell.com
The very amino-terminal domain of the huntingtin protein is directly located upstream of the
protein's polyglutamine tract, plays a decisive role in several important properties of this …

ATP synthase: a molecular therapeutic drug target for antimicrobial and antitumor peptides

Z Ahmad, F Okafor, S Azim… - Current medicinal …, 2013 - ingentaconnect.com
In this review we discuss the role of ATP synthase as a molecular drug target for natural and
synthetic antimicrobial/antitumor peptides. We start with an introduction of the universal …

A Computationally Designed Peptide Derived from Escherichia coli as a Potential Drug Template for Antibacterial and Antibiofilm Therapies

MH Cardoso, ES Candido, LY Chan… - ACS infectious …, 2018 - ACS Publications
Computer-aided screening of antimicrobial peptides (AMPs) is a promising approach for
discovering novel therapies against multidrug-resistant bacterial infections. Here, we …

Mechanism of antibacterial action of dermaseptin B2: Interplay between helix− hinge− helix structure and membrane curvature strain

C Galanth, F Abbassi, O Lequin, J Ayala-Sanmartin… - Biochemistry, 2009 - ACS Publications
Dermaseptin B2 (Drs B2) is a 33-residue-long cationic, α-helical antimicrobial peptide
endowed with membrane-damaging activity against a broad spectrum of microorganisms …

[HTML][HTML] PEGylation of the antimicrobial peptide LyeTx Ib maintains structure-related biological properties and improves selectivity

JC Moreira Brito, LR Carvalho… - Frontiers in Molecular …, 2022 - frontiersin.org
The biological activity of antimicrobial peptides and proteins is closely related to their
structural aspects and is sensitive to certain post-translational modifications such as …

The structural and topological analysis of membrane-associated polypeptides by oriented solid-state NMR spectroscopy: established concepts and novel …

B Bechinger, JM Resende, C Aisenbrey - Biophysical chemistry, 2011 - Elsevier
Solid-state NMR spectroscopy is a powerful technique for the investigation of membrane-
associated peptides and proteins as well as their interactions with lipids, and a variety of …

Molecular mechanism of antimicrobial excipient-induced aggregation in parenteral formulations of peptide therapeutics

M Li, BT Falk, X Lu, R Schroder, M Mccoy… - Molecular …, 2022 - ACS Publications
Antimicrobial preservatives are used as functional excipients in multidose formulations of
biological therapeutics to destroy or inhibit the growth of microbial contaminants, which may …