Nicotinic acetylcholine receptors are made up of homologous subunits, which are encoded
by a large multigene family. The wide number of receptor oligomers generated display …

Electron microscopy is the only currently available technique with a resolution adequate to
identify and follow every axon and dendrite in dense neuropil. Reconstructions of large …

Systems biology is an emerging discipline that combines high-content, multiplexed
measurements with informatic and computational modeling methods to better understand …

Electron tomography of thin sections of plastic-embedded biological material provides
valuable insights into the organellar organization of cells. With the advent of automated data …

Osteocytes are the most abundant cells in bone and the only cells embedded in the bone
mineral matrix. They form an extended, three-dimensional (3D) network, whose processes …

Nicotinic receptors are cation‐ion selective ligand‐gated ion channels that are expressed
throughout the nervous system. Most have significant calcium permeabilities, enabling them …

Neurotransmitter release is well known to occur at specialized synaptic regions that include
presynaptic active zones and postsynaptic densities. At cholinergic synapses in the chick …

There are fetal and adult subtypes of muscle nicotinic receptors (AChRs), whose structures
and functional roles are reasonably well known. Mutations of their subunits cause congenital …

We have developed a simplified, efficient approach for the 3D reconstruction and analysis of
mammalian cells in toto by electron microscope tomography (ET), to provide quantitative …

Regulation of intracellular calcium influences neuronal excitability, synaptic plasticity, gene
expression, and neurotoxicity. In this study, we investigated the role of calcium in …